DNA CLEAVAGE BY CATIONIC METALLOPORPHYRINS
DNA CLEAVAGE BY CATIONIC METALLOPORPHYRINS
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DOI：
10.1007/978-94-011-0255-1_16
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发表时间：
1995
期刊：
影响因子：
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通讯作者：
B. Meunier;G. Pratviel;J. Bernadou
中科院分区：
文献类型：
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作者：
B. Meunier;G. Pratviel;J. Bernadou
在过去的二十年里，关于氧化应激对细胞成分(DNA、蛋白质、脂类和碳水化合物)造成的结构损伤的化学和生化方面的许多数据已经发表。1 DNA的氧化损伤可以通过几种方法来启动：电离辐射，2光氧化(UV或可见光，带或不带光敏剂)，3由微量的外来过渡金属盐，4羟基自由基5或各种其他氧化剂激活的氢过氧化氢(有关DNA氧化降解的最新综述文章，见参考文献)。6)。在后一类药物中，我们发现像博莱霉素或具有烯二炔基序的药物，以及主要基于氧化还原活性的过渡金属络合物的化学核酸酶(有关最近的综述文章，见参考文献)。7，8)。DNA损伤可通过碱基或糖单元的氧化而产生。脱氧核糖的损伤会导致DNA链上一个碱基信息的丢失和/或可能对应于致命性损伤的DNA链断裂，特别是当氧化过程产生双链断裂(DSB)时，通过真正的DSB或通过相反链上的两个接近单链断裂(SSB)。
Within the two last decades, much data has been published on chemical and biochemical aspects of structural damages generated by oxidative stress on cellular constituents (DNA, proteins, lipids and carbohydrates).1Oxidative damage to DNA can be initiated by several methods: ionizing radiation,2photooxidation (UV or visible light with or without photosentitizers),3hydroperoxides activated by traces of adventitious transition metals salts,4 hydroxyl radicals5 or various other oxidizing agents (for a recent review article on the oxidative degradation of DNA, see ref. 6). In this latter category, we find cytotoxic drugs like bleomycin or agents having an enediyne motif, and chemical nucleases mainly based on redox-active transition metal complexes (for recent review articles, see ref. 7,8). DNA damages can be produced by oxidation of nucleobases or sugar units. Damages on deoxyribose lead to the loss of one base information and/or a break on a DNA strand which might correspond to a lethal lesion, especially when an oxidation process produces a doublestrand break (DSB), via a true DSB or via two near single-strand breaks (SSBs) on opposite strands.