The cytoplasmic face of cell contact sites.
The cytoplasmic face of cell contact sites.
复制标题
细胞接触位点的细胞质面。
DOI：
10.1016/s0959-440x(02)00318-4
复制
发表时间：
2002
影响因子：
6.8
通讯作者：
Weis,WilliamI
中科院分区：
文献类型：
--
作者：
Pokutta,Sabine;Weis,WilliamI
细胞接触位点的细胞质面包含将跨膜细胞粘附分子连接到细胞骨架的大分子组装体。这些组件是动态结构，是控制细胞粘附性的调节信号的目标。最近对钙粘蛋白-连环蛋白复合物、纽蛋白和埃兹蛋白/根蛋白/莫斯蛋白家族蛋白质的生物化学和结构的研究已经开始揭示这些组件的结构以及参与其调节的机制。
The cytoplasmic face of cell contact sites comprises large macromolecular assemblies that link transmembrane cell adhesion molecules to the cytoskeleton. These assemblies are dynamic structures that are the targets of regulatory signals that control cell adhesiveness. Recent studies of the biochemistry and structure of the cadherin–catenin complex, vinculin and proteins of the ezrin/radixin/moesin family have begun to reveal the architecture of these assemblies and the mechanisms that are involved in their regulation.