A Phase Separation Model for Transcriptional Control.
A Phase Separation Model for Transcriptional Control.
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DOI：
10.1016/j.cell.2017.02.007
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发表时间：
2017-03-23
期刊：
影响因子：
64.5
通讯作者：
Sharp PA
中科院分区：
文献类型：
--
作者：
Hnisz D;Shrinivas K;Young RA;Chakraborty AK;Sharp PA
超级增强子是控制基因转录的大簇增强子，在健康和患病状态下的细胞类型特异性过程中具有显着作用。目前缺乏解释有关超级增强子形成、功能和溶解的观察范围的模型。相分离的多分子组装体提供了划分细胞内生化反应的重要调节机制。我们提出相分离模型解释转录控制的特征，包括超级增强子的形成、超级增强子对扰动的敏感性及其转录爆发模式。该模型为进一步探索哺乳动物基因控制原理提供了一个概念框架。
Super-enhancers are large clusters of enhancers that control transcription of genes with prominent roles in cell-type specific processes in healthy and diseased states. A model that explains the spectrum of observations regarding super-enhancer formation, function and dissolution is lacking. Phase-separated multi-molecular assemblies provide an essential regulatory mechanism to compartmentalize biochemical reactions within cells. We propose that a phase separation model explains features of transcriptional control, including the formation of super-enhancers, the sensitivity of super-enhancers to perturbation, and their transcriptional bursting patterns. This model provides a conceptual framework to further explore principles of gene control in mammals.