Monoterpenes from Paeonia albiflora and Their Inhibitory Activity on Nitric Oxide Production by Lipopolysaccharide-Activated Microglia
Monoterpenes from Paeonia albiflora and Their Inhibitory Activity on Nitric Oxide Production by Lipopolysaccharide-Activated Microglia
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DOI：
10.1021/np9001898
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发表时间：
2009-09-01
影响因子：
5.1
通讯作者：
Qiu, Feng
中科院分区：
文献类型：
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作者：
Duan, Wen-Juan;Yang, Jing-Yu;Qiu, Feng
从芍药根60%乙醇提取物中分离得到了芍药苷(1)、芍药苷A(2)、芍药苷B(3)、芍药苷C(4)、芍药苷D(5)、芍药苷E(6)、芍药酮(7)、4- o -甲基苯甲酰芍药苷(8)、4- o -甲基没食子苷(9)、4- o -甲基去苯甲酰芍药苷（10）和4- o -甲基芍药苷（11）等11个新的单萜化合物。它们的结构主要是基于一维和二维核磁共振技术和质谱研究确定的。芍药苷D(5)和E(6)是前所未有的“笼状”单萜二聚体的例子。研究了分离得到的化合物对脂多糖激活的N9小胶质细胞产生一氧化氮的抑制作用。
Eleven new monoterpenes, paeonidangenin (1), paeonidanin A (2), paeonidanin B (3), paeonidanin C (4), paeonidanin D (5), paeonidanin E (6), paeoniflorone (7), 4-O-methylbenzoylpaeoniflorin (8), 4-O-methylgalloylpaeoniflorin (9), 4-O-methyldebenzoylpaeoniflorin (10), and 4-O-methylalbiflorin (11), were isolated from the 60% ethanol extract of the roots of Paeonia albiflora. Their structures were determined primarily on the basis of 1D and 2D NMR techniques and MS studies. Paeonidanins D (5) and E (6) are unprecedented examples of "cage-like" monoterpene dimers. The inhibitory effects of the isolated compounds on nitric oxide production by lipopolysaccharide (LPS)-activated N9 microglia were evaluated.