Drug interactions in antiarrhythmic therapy.
Drug interactions in antiarrhythmic therapy.
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抗心律失常治疗中的药物相互作用。
DOI：
10.1111/j.1749-6632.1984.tb20781.x
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发表时间：
1984
影响因子：
5.2
通讯作者：
Giardina,EG
中科院分区：
文献类型：
--
作者：
BiggerJr,JT;Giardina,EG
大多数心律失常患者患有心脏病和非心律失常功能障碍，例如心室衰竭、心绞痛或高血压。服用抗心律失常药物的患者很可能服用其他心血管药物来治疗这些并存的问题。此外，由于年龄和其他因素，服用抗心律失常药物的患者也可能服用一种或多种非心血管药物。最后，值得注意的是，服用心血管药物的患者对药物相互作用的耐受性可能相当低。例如，正常年轻人可能可以很好地耐受由药物相互作用引起的体位性低血压。然而，左心室储备较差或冠状动脉或颈动脉严重狭窄的患者对体位性低血压的耐受性较差。在本文中，我们将讨论涉及抗心律失常药物的不良药物相互作用。
Most patients who have cardiac arrhythmias have heart disease and nonarrhythmic dysfunction, for example, ventricular failure, angina pectoris, or hypertension. Patients who take antiarrhythmic drugs are very likely to take other cardiovascular drugs to treat these coexistent problems. Also, because of age and other factors, patients taking antiarrhythmic drugs are likely to take one or more noncardiovascular drugs as well. Finally, it is notable that the tolerance for a drug interaction may be quite low in patients who take cardiovascular drugs. For example, postural hypotension caused by a drug interaction might be well tolerated in a normal young person. Patients with poor left ventricular reserve or with critical stenosis of coronary or carotid arteries, however, tolerate postural hypotension poorly. In this paper, we will discuss adverse drug interactions involving antiarrhythmic drugs.