Libraries of 2,3,4,6,7,11b-Hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine Derivatives via a Multicomponent Assembly Process/1,3-Dipolar Cycloaddition Strategy
Libraries of 2,3,4,6,7,11b-Hexahydro-1H-pyrido[2,1-a]isoquinolin-2-amine Derivatives via a Multicomponent Assembly Process/1,3-Dipolar Cycloaddition Strategy
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DOI：
10.1021/co2001636
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发表时间：
2012-01-01
影响因子：
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通讯作者：
Martin, Stephen F.
中科院分区：
文献类型：
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作者：
Granger, Brett A.;Kaneda, Kyosuke;Martin, Stephen F.
已经开发了曼尼希型多组分组装过程/1，3-偶极环加成策略用于快速有效地构建母体四氢异喹啉稠合的异恶唑烷支架，随后使用完善的方案将其官能化以获得新颖的2，3，4，6，7，11b-六氢-1H-吡啶并[2，1-a]异喹啉-2-胺衍生物的多样化70元文库。
A Mannich-type multicomponent assembly process/1,3-dipolar cycloaddition strategy has been developed for the rapid and efficient construction of a parent tetrahydroisoquinoline fused isoxazolidine scaffold, which was subsequently functionalized using well-established protocols to access a diverse 70-membered library of novel 2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinoline-2-amine derivatives.