Serum-soluble selectin levels in patients with rheumatoid arthritis and systemic sclerosis
Serum-soluble selectin levels in patients with rheumatoid arthritis and systemic sclerosis
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DOI：
10.1111/j.0300-9475.2004.01389.x
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发表时间：
2004-03-01
影响因子：
3.7
通讯作者：
Duman, M
中科院分区：
文献类型：
--
作者：
Ates, A;Kinikli, G;Duman, M
可溶性选择素可能在炎症反应中发挥调节作用，而炎症反应是风湿性疾病(如类风湿性关节炎(RA)和系统性硬化症(SSC))病理生理学的关键。本研究的目的是研究血清可溶性(S)选择素水平升高是否与类风湿关节炎或硬化性硬化症相关。采用双抗体夹心酶联免疫吸附试验检测34例RA患者、30例SSC患者和16例健康人血清sE-、sL-和sP-选择素水平。RA和SSc患者血清sE-选择素水平明显高于正常对照组。类风湿关节炎患者的sL-选择素水平显著低于健康对照组。各研究组间血清sP-选择素水平差异无统计学意义。活动期RA患者血清sE-和sL-选择素水平显著高于非活动期RA患者。此外，还观察到RA患者的血清选择素水平与疾病活动性指标如血沉和C反应蛋白之间存在一定的相关性。SSC合并肺纤维化患者血清sE-选择素水平较高，且一氧化碳弥散量与血清sE-选择素水平呈负相关。血清选择素水平可能为类风湿关节炎患者的疾病活动性和SSc患者的疾病严重程度提供有用的额外标志物。
Soluble forms of selectins may play a regulatory role in inflammatory responses that are key to the pathophysiology of rheumatic diseases such as rheumatoid arthritis (RA) and systemic sclerosis (SSc). The aim of this study was to examine whether the elevated serum-soluble (s) selectin levels are associated with RA or SSc. Serum sE-, sL- and sP-selectin levels were measured by sandwich enzyme-linked immunosorbent assay in 34 RA patients, 30 SSc patients and 16 healthy subjects. The levels of sE-selectin were significantly higher in RA and SSc patients than those in healthy subjects. The sL-selectin level was significantly lower in RA patients compared to healthy subjects. Serum sP-selectin levels were not significantly different among the study groups. The active RA patients had significantly higher serum sE- and sL-selectin levels compared to inactive RA patients. Also, some correlations were observed between the serum selectin levels and measures of disease activity such as erythrocyte sedimentation rate and C-reactive protein in RA patients. The higher levels of sE-selectin were found in SSc patients with pulmonary fibrosis, and there was also a negative correlation between diffusion capacity for carbon monoxide and serum sE-selectin. Serum levels of selectins may provide a useful additional marker for disease activity in RA patients and for disease severity in SSc patients.