Individual variation in susceptibility to extracranial carotid atherosclerosis.
Individual variation in susceptibility to extracranial carotid atherosclerosis.
复制标题
颅外颈动脉粥样硬化易感性的个体差异。
DOI：
10.1161/01.atv.8.4.389
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Crouse3rd,JR
中科院分区：
文献类型：
--
作者：
Rubens,J;Espeland,MA;Ryu,J;Harpold,G;McKinney,WM;Kahl,FR;Toole,JF;Crouse3rd,JR
我们评估了冠心病的危险因素，并采用无创方法量化382例无脑血管症状的患者颅外颈动脉粥样硬化的程度。参与者的年龄从27岁到80岁不等。其中男性183人，女性199人，黑人30人，白人352人。所有患者均有心脏病症状，并住院进行冠状动脉造影。在这一系列接受冠状动脉造影的患者中，危险因素与颅外颈动脉粥样硬化程度的相关性揭示了依赖于冠状动脉状态的危险因素与颈动脉粥样硬化之间关系的个体差异。冠心病患者和非冠心病患者颈动脉粥样硬化的危险因素存在差异。年龄和高血压与颈动脉粥样硬化独立相关，无论是有冠状动脉疾病的患者还是没有冠状动脉疾病的患者。然而，其他危险因素与颈动脉粥样硬化仅在一组或另一组中相关。危险因素与冠心病患者颈动脉粥样硬化的相关性较强（r2 = 0.41），而与无冠心病患者的相关性较差（r2 = 0.21）。某些危险因素（年龄、吸烟年数、左心室肥厚）与冠心病患者颈动脉粥样硬化程度的相关性不同。澄清冠状动脉状态在颈动脉粥样硬化对危险因素的反应中的作用，可以部分解释某些基于人群的研究结果，这些研究与种族、性别和其他颈动脉粥样硬化危险因素有关。（摘要删节250字）
Risk factors for coronary disease were assessed and noninvasive methods were used to quantitate the extent of extracranial carotid atherosclerosis in 382 patients free of cerebrovascular symptoms. The ages of the participants ranged from 27 to 80 years. There were 183 men and 199 women, 30 black and 352 white persons. All patients had heart disease symptoms and were hospitalized for coronary angiography. Correlation of risk factors with extent of extracranial carotid atherosclerosis in this series of patients undergoing coronary angiography uncovered individual variability in relationships between risk factors and carotid atherosclerosis that depended on coronary status. Risk factors for carotid atherosclerosis in patients with and without coronary disease differed. Age and hypertension were independently related to carotid atherosclerosis in patients with, as well as those without, coronary disease. However, other risk factors were related to carotid atherosclerosis in only one group or the other. Risk factors correlated strongly with carotid atherosclerosis in patients with coronary disease (r2 = 0.41) but poorly in those with no coronary disease (r2 = 0.21). Certain risk factors (age, pack years of smoking, left ventricular hypertrophy) related differently to the extent of carotid atherosclerosis in patients with, than in those without, coronary disease. Clarification of the role of coronary status in the carotid atherosclerosis response to risk factors may partly explain the results of certain population-based studies that have related race, gender, and other risk factors to carotid atherosclerosis.(ABSTRACT TRUNCATED AT 250 WORDS)