"O-acyl isopeptide method" for peptide synthesis:: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH
"O-acyl isopeptide method" for peptide synthesis:: synthesis of forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH
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DOI：
10.1039/b702284k
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发表时间：
2007-01-01
影响因子：
3.2
通讯作者：
Kiso, Yoshiaki
中科院分区：
文献类型：
--
作者：
Yoshiya, Taku;Taniguchi, Atsuhiko;Kiso, Yoshiaki
O-酰基异肽法作为一种高效的肽合成方法，近年来受到关注。本文采用两步合成法，不经差向异构化，有效地合成了40种“O-酰基异二肽单元”Boc-Ser/Thr（Fmoc-Xaa）-OH（1-40）。O-酰基异二肽单元是能够常规使用O-酰基异肽方法的重要结构单元。
The O-acyl isopeptide method has recently received attention as an efficient synthetic method for peptides. Herein, forty kinds of "O-acyl isodipeptide unit" Boc-Ser/Thr(Fmoc-Xaa)-OH (1-40) were effectively synthesized in two-steps without epimerization. The O-acyl isodipeptide units are important building blocks to enable the routine use of the O-acyl isopeptide method.