Antigen processing gene polymorphisms in HLA‐DR2 multiple sclerosis
Antigen processing gene polymorphisms in HLA‐DR2 multiple sclerosis
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HLA-DR2 多发性硬化症的抗原加工基因多态性
DOI：
10.1212/wnl.43.6.1192
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发表时间：
1993
期刊：
影响因子：
9.9
通讯作者：
H. Mcdevitt
中科院分区：
文献类型：
--
作者：
R. Liblau;P. Endert;M. Sandberg;S. Patel;M. T. Lopez;S. Land;L. Fugger;H. Mcdevitt
多发性硬化症（MS）和HLA II类基因的等位基因之间的关联表明，至少有一个MS易感基因与HLA II类区域相关。然而，尚未确切查明实际的责任所在。最近克隆的新基因参与抗原处理的地图内的HLA II类区域使我们调查-使用限制性片段长度多态性（RFLP）技术和序列特异性寡核苷酸分析-这些基因是否可能发挥作用，赋予MS的易感性。我们研究了大的多功能蛋白酶（LMP）2和7和转运相关抗原处理（TAP）对60例HLA-DR 2 MS患者和60例健康对照者的HLA-DR 2基因1和2多态性进行了分析，未发现MS患者组中存在特异性或偏好性RFLP模式或编码序列变异。我们的数据不支持这些基因在MS易感性中的作用。
The association between multiple sclerosis (MS) and alleles of the HLA class II genes indicates that at least one MS susceptibility gene is linked to the HLA class II region. However, the actual locus responsible has not been precisely identified. The recent cloning of new genes involved in antigen processing that map within the HLA class II region led us to investigate–using the restriction fragment length polymorphism (RFLP) technique and sequence-specific oligonucleotide analysis–whether these genes might play a role in conferring susceptibility to MS. We studied large multifunctional protease (LMP) 2 and 7 and transporter associated with antigen processing (TAP) 1 and 2 gene polymorphisms in 60 HLA-DR2 MS patients and 60 HLA-DR2 healthy subjects and found no specific or preferential RFLP patterns or coding sequence variants in the patient group. Our data do not support a role for these genes in MS susceptibility.
DOI：
10.1073/pnas.89.9.3932
发表时间：
1992-05-01
影响因子：
11.1
作者：
COLONNA, M;BRESNAHAN, M;SPIES, T
通讯作者：
SPIES, T