Managing the complexity of communication: regulation of gap junctions by post-translational modification.
Managing the complexity of communication: regulation of gap junctions by post-translational modification.
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DOI：
10.3389/fphar.2013.00130
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发表时间：
2013-10-22
影响因子：
5.6
通讯作者：
Nielsen MS
中科院分区：
文献类型：
--
作者：
Axelsen LN;Calloe K;Holstein-Rathlou NH;Nielsen MS
间隙连接由连接蛋白组成，连接蛋白形成细胞间通道，连接相邻细胞以适应信息交换。然而，对沟通的需求确实会随着时间的推移而变化，因此必须严格控制。虽然通过转录和翻译调控连接蛋白的表达非常重要，但运输、通道活性和降解也受到严格控制。连接蛋白的功能可以通过几种翻译后修饰来调节，这些修饰影响许多参数;包括通道数量、开放概率、单通道电导或选择性。最广泛研究的翻译后修饰是磷酸化，这在所有哺乳动物连接蛋白中均有记载。除了磷酸化，已知一些连接蛋白被泛素化、SUMO化、亚硝基化、羟基化、乙酰化、甲基化和γ-羧基谷氨酸化。本综述的目的是总结我们目前的知识，翻译后调控的连接蛋白家族的蛋白质。
Gap junctions are comprised of connexins that form cell-to-cell channels which couple neighboring cells to accommodate the exchange of information. The need for communication does, however, change over time and therefore must be tightly controlled. Although the regulation of connexin protein expression by transcription and translation is of great importance, the trafficking, channel activity and degradation are also under tight control. The function of connexins can be regulated by several post translational modifications, which affect numerous parameters; including number of channels, open probability, single channel conductance or selectivity. The most extensively investigated post translational modifications are phosphorylations, which have been documented in all mammalian connexins. Besides phosphorylations, some connexins are known to be ubiquitinated, SUMOylated, nitrosylated, hydroxylated, acetylated, methylated, and γ-carboxyglutamated. The aim of the present review is to summarize our current knowledge of post translational regulation of the connexin family of proteins.
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