Risks for Preeclampsia and Small for Gestational Age: Predictive Values of Placental Growth Factor, Soluble fms-like Tyrosine Kinase-1, and Inhibin A in Singleton and Multiple-Gestation Pregnancies
Risks for Preeclampsia and Small for Gestational Age: Predictive Values of Placental Growth Factor, Soluble fms-like Tyrosine Kinase-1, and Inhibin A in Singleton and Multiple-Gestation Pregnancies
复制标题
DOI：
10.1055/s-0032-1329691
复制
发表时间：
2013-08-01
影响因子：
2
通讯作者：
Audibert, Francois
中科院分区：
文献类型：
--
作者：
Boucoiran, Isabelle;Thissier-Levy, Sarah;Audibert, Francois
目的探讨胎盘生长因子（PlGF）、可溶性fms样酪氨酸激酶-1（sFlt-1）和抗氧化剂结合蛋白A（BFA）在单胎和多胎妊娠中预测子痫前期（PE）和小于胎龄儿（SGA.Study Design）的准确性。在妊娠12 ~ 18周（第1次访视）和24 ~ 26周（第2次访视）评价血浆生物标志物，并以中位数的校正倍数表示。PlGF是PE和SGA的最佳预测因子。在10%的假阳性率下，访视1时PlGF预测单胎妊娠PE的敏感性为21%，而多胎妊娠PE的敏感性为60%。PlGF在第1次访视时有31%的敏感性，在单胎和27%的多胎妊娠为SGA prediction. ConclusionPlGF水平是一个很好的预测随后的PE早在12至18周的多胎妊娠，但没有足够的临床有用的被用作一个单一的标记物。
Objective To determine the accuracy of placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1), and inhibin A in singleton and multiple-gestation pregnancies for predicting preeclampsia (PE) and small for gestational age (SGA).Study Design A prospective cohort nested in a randomized controlled trial of antioxidant supplementation for the prevention of PE. Plasma biomarkers were evaluated at 12 to 18 (visit 1) and 24 to 26 (visit 2) weeks' gestation and expressed as adjusted multiples of the median.Results Multiple-gestation pregnancy (74/772) had a significant impact on all biomarkers' levels. PlGF was the best predictor of PE and SGA. At a 10% false-positive rate, PlGF at visit 1 had 21% sensitivity for predicting PE in singleton versus 60% in multiple-gestation pregnancies. PlGF at visit 1 had a 31% sensitivity in singleton and 27% in multiple-gestation pregnancies for SGA prediction.Conclusion PlGF level was a good predictor of subsequent PE as early as 12 to 18 weeks in multiple-gestation pregnancies but was not clinically useful enough to be used as a single marker.