The relationship between the Feline Coronavirus anti-body titre and the age, breed, gender and health status of Australian cats
The relationship between the Feline Coronavirus anti-body titre and the age, breed, gender and health status of Australian cats
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DOI：
10.1111/j.1751-0813.2006.tb13114.x
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发表时间：
2006-01-01
影响因子：
1.1
通讯作者：
Norris, JM
中科院分区：
文献类型：
--
作者：
Bell, ET;Malik, R;Norris, JM
目的探讨澳大利亚猫冠状病毒（FCoV）抗体滴度与年龄、品种、性别和健康状况的关系。设计回顾性研究方法2年内记录两种测定FCoV抗体水平的血清学试验（冠状病毒酶试验和7 B猫传染性腹膜炎（FIP）试验）的结果，包括患者体征、病史、提出投诉及要求进行测试的理由每个抗体检测的结果与四个解释变量有关（采血时的品种、年龄、性别和健康状况），使用单变量有序逻辑回归分析，Mann Whitney U检验，单样本符号检验或Kruskal-Wallis分析（如适用）。结果共检测冠状病毒抗体637例，7 B FIP抗体191例。不同品种猫血清冠状病毒抗体效价差异有统计学意义（P < 0.0005）。暹罗猫、波斯猫、家猫和孟加拉猫的冠状病毒抗体滴度中位数（100）显著低于英短、康沃尔语、雷克斯和缅甸猫（400，P < 0.0005）。冠状酶或7 B FIP抗体滴度与年龄、性别或总体健康状况之间没有统计学关系，结论本研究加强了解释健康猫和具有与FIR相容的体征的患者的FCoV血清学试验的复杂性。和中值FCoV抗体滴度。这支持了在对FCoV感染的反应中存在品种相关差异的理论。冠状病毒抗体滴度中位数的分布品种是非常相似的模式，最近在悉尼报道的FIP的品种易感性。
Objectives To investigate the relationship between Feline Coronavirus (FCoV) antibody titres and age, breed, gender and health status of Australian catsDesign Retrospective studyProcedure Results from two serological tests that measure FCoV antibody levels, the Coronase test and the 7B Feline Infectious Peritonitis (FIP) test, were recorded over a 2-year period, with patient signalment, history, presenting complaint and the reason for ordering the test (as available).Results from each antibody test were related to four explanatory variables (breed, age, gender and health status at the time of blood collection) using univariate ordinal logistic regression analyses, Mann Whitney U tests, one-sample sign tests or Kruskal-Wallis analyses, as appropriate. Results Results from 637 Coronase and 191 7B FIP antibody tests were recorded. There were significant differences in median Coronase antibody titres between breeds of cats (P < 0.0005). Specifically, the median Coronase antibody titres of Siamese, Persians, Domestic Shorthairs and Bengal cats (100) were significantly lower than that of British Shorthairs, Cornish Rex and Burmese cats (400, P < 0.0005). There was no statistical relationship between the Coronase or 7B FIP antibody titres and age, gender or overall health status, even when considering only those cats in which clinical signs suggestive of FIP were present.Conclusion This study reinforces the complexity of interpreting serological tests for FCoV in both healthy cats and patients with signs compatible with FIR Unique to this study is the detection of a significant relationship between breed and median FCoV antibody titre. This supports the theory that breed related differences exist in response to FCoV infection. The distribution of median Coronase antibody titres by breed was very similar to the pattern of breed predisposition to FIP recently reported in Sydney.