Sorting it out: regulation of exosome loading.
Sorting it out: regulation of exosome loading.
复制标题
整理出来：外泌体负载的调节。
DOI：
10.1016/j.semcancer.2014.04.009
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发表时间：
2014-10
影响因子：
14.5
通讯作者：
Mittelbrunn M
中科院分区：
文献类型：
--
作者：
Villarroya-Beltri C;Baixauli F;Gutiérrez-Vázquez C;Sánchez-Madrid F;Mittelbrunn M
细胞外小泡是细胞持续分泌到细胞外环境中的一种新的细胞间通讯媒介，它既包括细胞内来源的外体，也包括来自质膜的小泡。外切体包含特定的蛋白质和RNA酶系，表明存在控制分子分选的机制。尽管调控蛋白质装载到外切体的分子机制已经研究了多年，但直到最近，RNA的分类一直难以捉摸。在这里，我们回顾了控制分子分选成外体的分子机制，特别是RNA的分选。我们还讨论了细胞环境如何影响外切体的组成，从而影响外切体生产者和受体细胞之间的通讯结果，特别是肿瘤细胞之间的通讯以及与肿瘤微环境中的细胞的通讯。
Extracellular vesicles (EVs), a term that includes both exosomes of endocytic origin and vesicles derived from plasma membranes, are continuously secreted by cells to the extracellular environment, and represent a novel vehicle for cell-cell communication. Exosomes contain specific repertoires of proteins and RNAs, indicating the existence of mechanisms that control the sorting of molecules into them. Although the molecular mechanisms that regulate the loading of proteins into exosomes have been studied for years, the sorting of RNA has been elusive until recently. Here we review the molecular mechanisms that control the sorting of molecules into exosomes, with special attention to the sorting of RNA. We also discuss how the cellular context affects the composition of exosomes, and thus the outcome of the communication between the exosome-producer and recipient cells, with particular focus on the communication between tumor cells and with cells of the tumor microenvironment.