A randomized trial of the effect of a walking regimen on the functional status of 100 adult allogeneic donor hematopoietic cell transplant patients
A randomized trial of the effect of a walking regimen on the functional status of 100 adult allogeneic donor hematopoietic cell transplant patients
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DOI：
10.1016/j.bbmt.2007.04.008
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发表时间：
2007-08-01
影响因子：
4.3
通讯作者：
Weisdorf, Daniel J.
中科院分区：
文献类型：
--
作者：
DeFor, Todd E.;Burns, Linda J.;Weisdorf, Daniel J.
为了研究运动对成人异基因造血细胞移植受者的影响，我们将100名患者随机分为结构化步行方案和没有正式运动方案的对照组。从入院移植当天开始，运动臂的患者被要求在医院期间每天在跑步机上行走两次，每次15分钟。出院后，他们被要求每天步行一次，持续30分钟。运动计划的效果主要是通过移植入院到移植后第100天的Karnofsky评分(KPS)的变化来衡量的，这是由被分配的运动方案盲目的主治医生评分的。运动组KPS的下降幅度小于对照组：10分对20分。这一差异在总研究人群中没有统计学意义(P=.21)，但在接受非清髓性移植前调理的老年和健康状况较差的患者亚组中有统计学意义(P=.04)。在运动组中，在第100天基线KPS为90的患者中，64%的患者与对照组的18%相比(P=0.03)。两组基线评分均为90分的患者中，有32%的患者在第100天时评分均为90(P=0.99)。出院时患者自评的身心幸福感得分分析显示，运动组的身体幸福感得分较高(P
To investigate the impact of exercise on adult allogeneic hematopoietic cell transplant recipients, we randomized 100 patients to either a structured walking regimen or to a control group with no formal exercise program. Starting on the day of admission for transplant, patients in the exercise arm were asked to walk on a treadmill twice a day for 15 minutes while in the hospital. After discharge, they were asked to walk once a day for 30 minutes. The effect of the exercise program was primarily measured by the change in the Karnofsky score (KPS) from transplant admission to day 100 posttransplant, which was scored by the attending physician who was blinded to the assigned exercise regimen. The decline in KPS was smaller in the exercise group than in the control group: 10 points versus 20 points. This difference was not statistically significant in the total study population (P =.21) but was statistically significant among the subset of older and less fit patients receiving nonmyeloablative pretransplant conditioning (P =.04). Sixty-four percent of patients on the exercise arm who had a baseline KPS = 90 by day 100 compared to 18% of the control arm (P =.03). Thirty-two percent of patients with a baseline score >= 90 had a score >= 90 by day 100 in both groups (P =.99). Analyses of patients' self reported scores at the time of discharge for physical and emotional well-being showed that the exercise arm had better scores for physical well-being (P