Latent periodicity of serine-threonine and tyrosine protein kinases and other protein families
Latent periodicity of serine-threonine and tyrosine protein kinases and other protein families
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DOI：
10.1016/j.compbiolchem.2005.04.003
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发表时间：
2005-06-01
影响因子：
3.1
通讯作者：
Korotkov, EV
中科院分区：
文献类型：
--
作者：
Laskin, AA;Kudryashov, NA;Korotkov, EV
我们发现了大约85%的带注释的丝氨酸-苏氨酸和酪氨酸蛋白激酶的催化结构域的潜在周期性。其他22个蛋白家族和结构域也得到了类似的结果。我们还设计了噪声分解方法，旨在区分相同周期长度的不同周期类型。该方法将与循环剖面对准方法结合使用，这种组合能够揭示与结构相关或与功能相关的潜在周期性模式。讨论了蛋白激酶活性位点周期结构的可能起源。综上所述，我们认为潜在周期性是许多催化蛋白结构域的共同特性。(c) 2005 Elsevier Ltd版权所有。
We identified latent periodicity in catalytic domains of approximately 85% of annotated serine-threonine and tyrosine protein kinases. Similar results were obtained for other 22 protein families and domains. We also designed the method of noise decomposition, which is aimed to distinguish between different periodicity types of the same period length. The method is to be used in conjunction with the method of cyclic profile alignment, and this combination is able to reveal structure-related or function-related patterns of latent periodicity. Possible origins of the periodic structure of protein kinase active sites are discussed. Summarizing, we presume that latent periodicity is the common property of many catalytic protein domains. (c) 2005 Elsevier Ltd. All rights reserved.