Preoperative assessment of skeletal muscle mass during magnetic resonance enterography in patients with Crohn's disease.
Preoperative assessment of skeletal muscle mass during magnetic resonance enterography in patients with Crohn's disease.
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DOI：
10.1007/s13304-020-00790-x
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发表时间：
2021-08
影响因子：
2.6
通讯作者：
Luxton S
中科院分区：
文献类型：
--
作者：
Celentano V;Kamil-Mustafa L;Beable R;Ball C;Flashman KG;Jennings Z;O' Leary DP;Higginson A;Luxton S
腰大肌面积的测量已被用于估计瘦肌肉质量，作为肌肉减少症的替代指标，但关于肌肉减少症对炎症性肠病手术后临床结果的影响，缺乏证据。本研究的目的是评估MRI肠造影定义的肌少症与克罗恩病患者择期回盲切除术后并发症之间的关系。为了测量腰肌的横截面积，使用徒手面积工具在L4水平上描出每条腰肌的边缘，并记录其总和为总腰肌面积（Total psoas area， TPA）。腹壁的总横截肌面积记录为骨骼肌面积（SMA），而肌骨化症是通过将腰肌强度与脑脊液平均强度归一化来测量的。主要结局是TPA和SMA最低四分位数患者术后30天并发症的发生率。纳入31例患者，10例（32.25%）患者在手术30天内出现术后并发症。TPA最低四分位数的临界值男性为11.93 cm2，女性为9.77 cm2，共包括8例（25.8%）患者，该组5例（62.5%）患者出现术后并发症，3例（37.5%）患者出现Clavien-Dindo≥3级并发症。SMA最低四分位数的临界值为男性73.49 cm2，女性65.85 cm2, 8例患者中有4例（50%）出现术后并发症。腰肌横截面积和骨量面积可以在磁共振肠图上估计作为肌肉减少症的替代标记，观察者之间的一致性很高。
Measurement of the psoas muscle area has been applied to estimate lean muscle mass as a surrogate marker of sarcopenia, but there is a paucity of evidence regarding the influence of sarcopenia on clinical outcomes following inflammatory bowel disease surgery. The aim of this study was to evaluate the association between MRI enterography defined sarcopenia and postoperative complications in patients undergoing elective ileocaecal resection for Crohn’s disease. To obtain cross sectional area measurement of the psoas muscle, the freehand area tool was used to trace the margin of each psoas muscle at the level of L4, with the sum recorded as Total Psoas Area (TPA). The total cross sectional muscle area of the abdominal wall was recorded as Skeletal Muscle Area (SMA), while myosteatosis was measured by normalising the psoas muscle intensity with the mean intensity of the cerebrospinal fluid. The primary outcome was the incidence of 30-day postoperative complications in patients in the lowest quartile of TPA and SMA. 31 patients were included and ten patients (32.25%) developed postoperative complications within 30 days of surgery. The cut-off values for the lowest quartile for TPA were 11.93 cm2 in men and 9.77 cm2 in women, including a total of 8 patients (25.8%) with 5 patients in this group (62.5%) developing postoperative complications and 3 patients (37.5%) Clavien-Dindo class ≥ 3 complications. The cut-off values for the lowest quartile for SMA were 73.49 cm2 in men and 65.85 cm2 in women, with 4 patients out of 8 (50%) developing postoperative complications. Psoas muscle cross sectional area and skeletal mass area can be estimated on Magnetic Resonance Enterography as surrogate markers of sarcopenia with high inter-observer agreement.
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影响因子：
0.8
作者：
Celentano V
通讯作者：
Celentano V
影响因子：
3.7
作者：
Bamba S;Sasaki M;Takaoka A;Takahashi K;Imaeda H;Nishida A;Inatomi O;Sugimoto M;Andoh A
通讯作者：
Andoh A
影响因子：
8
作者：
Cushing, Kelly C.;Kordbacheh, Hamed;Ananthakrishnan, Ashwin N.
通讯作者：
Ananthakrishnan, Ashwin N.
影响因子：
3.4
作者：
Khan, Amir Ishaq;Reiter, David A.;Master, Viraj A.
通讯作者：
Master, Viraj A.
影响因子：
8
作者：
Calvet, Xavier;Panes, Julian;Roldan, Julio
通讯作者：
Roldan, Julio