Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids.
Tissue-specific expression of the rat albumin gene: genetic control of its extinction in microcell hybrids.
复制标题
大鼠白蛋白基因的组织特异性表达：微细胞杂交中其灭绝的遗传控制。
DOI：
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发表时间：
1986
影响因子：
11.1
通讯作者：
M. Weiss
中科院分区：
文献类型：
--
作者：
C. Petit;J. Levilliers;M. Ott;M. Weiss
Numerous studies of cell hybrids have indicated that somatic cells produce negative regulators (extinguishers) that prevent the expression of functions foreign to their own differentiation. Here, we report genetic evidence of such control. In microcell hybrids between well-differentiated rat hepatoma cells and microcells of mouse fibroblast L cells, the extinction of albumin synthesis is directly related to the presence of a single specific chromosome of the mouse fibroblast parent. The expression of several other hepatic functions is not affected. Transfection of these hybrids with a recombinant plasmid, containing a tissue-specific control element of the upstream region of the rat albumin gene linked to coding sequences of the chloramphenicol acetyltransferase gene, reveals that extinction acts on or via this cis-control element.
