BLUNTING OF NEUROENDOCRINE RESPONSES TO INFUSION OF L-TRYPTOPHAN IN WOMEN WITH PERIMENSTRUAL MOOD CHANGE
BLUNTING OF NEUROENDOCRINE RESPONSES TO INFUSION OF L-TRYPTOPHAN IN WOMEN WITH PERIMENSTRUAL MOOD CHANGE
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DOI：
10.1017/s0033291700020407
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发表时间：
1991-05-01
影响因子：
6.9
通讯作者：
GOODWIN, G
中科院分区：
文献类型：
--
作者：
BANCROFT, J;COOK, A;GOODWIN, G
在月经周期的两个阶段，月经前和月经后，在13名妇女和13名妇女没有经前抑郁症（MC和NMC组分别）的L-色氨酸输注的神经内分泌反应进行了测量。 先前的研究表明，在非抑郁症女性中，这种挑战测试会导致循环中催乳素和生长激素的增加。 在抑郁的女性中，这两种反应都是迟钝的。 在这项研究中，生长激素和皮质醇的反应都较小的MC组比NMC组在这两个场合。 催乳素反应在两组中均在产后较产后减弱。 这些发现表明，经历经前抑郁症的女性在整个月经周期中可能存在神经内分泌异常。 这些改变的内分泌反应中反映的神经递质异常似乎与通常发生在产前的神经内分泌变化相互作用，导致在该周期阶段易患抑郁症。
The neuroendocrine response to L-tryptophan infusion was measured at two stages of the menstrual cycle, premenstrually and postmenstrually, in 13 women with and 13 women without premenstrual depression (the MC and NMC groups respectively). Previous studies have shown that in non-depressed women, this challenge test results in an increase in circulating prolactin and growth hormone. In depressed women both responses are blunted. In this study the growth hormone and cortisol responses were smaller in the MC group than the NMC group on both occasions. The prolactin response was blunted premenstrually compared with postmenstrually in both groups. These findings suggest that women who experience premenstrual depression may have neuroendocrine abnormalities throughout the cycle. The neurotransmitter abnormalities reflected in these altered endocrine responses appear to interact with neuroendocrine changes that normally occur premenstrually resulting in a vulnerability to depression at that phase of the cycle.