Dynamic reciprocity in the wound microenvironment.
Dynamic reciprocity in the wound microenvironment.
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DOI：
10.1111/j.1524-475x.2011.00673.x
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发表时间：
2011-03
期刊：
影响因子：
--
通讯作者：
Herman IM
中科院分区：
文献类型：
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作者：
Schultz GS;Davidson JM;Kirsner RS;Bornstein P;Herman IM
在这里，我们将动态互易性（DR）定义为细胞及其周围微环境之间持续的双向相互作用。在综述中，我们认为DR在伤口愈合过程中特别有意义，因为DR驱动的生物化学，生物物理和细胞损伤反应在调节组织再生反应中起着关键作用。这样的细胞-细胞外基质相互作用不仅引导和调节细胞形态，而且引导和调节组织发育（包括例如胚胎发生、血管生成）期间以及病理过程（包括癌症、糖尿病、高血压和慢性伤口愈合）期间的细胞分化、迁移、增殖和存活。在此，我们研究了伤口微环境中的DR，同时考虑了急性和慢性伤口愈合的具体例子。这篇综述还考虑了如何试图解释慢性伤口病理生理学，这可能是在DR框架内理解的一些假设。应用动态互惠的原则，以优化伤口护理实践和未来发展的创新伤口愈合疗法的影响也被简要考虑。
Here, we define dynamic reciprocity (DR) as an ongoing, bidirectional interaction amongst cells and their surrounding microenvironment. In the review, we posit that DR is especially meaningful during wound healing as the DR-driven biochemical, biophysical and cellular responses to injury play pivotal roles in regulating tissue regenerative responses. Such cell-extracellular matrix interactions not only guide and regulate cellular morphology, but cellular differentiation, migration, proliferation, and survival during tissue development, including e.g. embryogenesis, angiogenesis, as well as during pathologic processes including cancer diabetes, hypertension and chronic wound healing. Herein, we examine DR within the wound microenvironment while considering specific examples across acute and chronic wound healing. This review also considers how a number of hypotheses that attempt to explain chronic wound pathophysiology, which may be understood within the DR framework. The implications of applying the principles of dynamic reciprocity to optimize wound care practice and future development of innovative wound healing therapeutics are also briefly considered.