Essential fatty acid metabolism and its modification in atopic eczema
Essential fatty acid metabolism and its modification in atopic eczema
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DOI：
10.1093/ajcn/71.1.367s
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发表时间：
2000-01-01
影响因子：
7.1
通讯作者：
Horrobin, DF
中科院分区：
文献类型：
--
作者：
Horrobin, DF
20世纪30年代至50年代的研究表明，n-6必需脂肪酸（EFA）的缺乏会导致动物和人类的炎症性皮肤病。在一种常见的遗传性皮肤病，特应性皮炎（湿疹），有证据表明，低血EFA浓度和治疗反应，特别是高剂量的亚油酸。最近，已经确定特应性湿疹中不存在亚油酸缺乏。亚油酸的浓度反而倾向于在患有特应性湿疹的患者的血液、乳汁和脂肪组织中升高，而亚油酸代谢物的浓度显著降低。这表明亚油酸向γ-亚麻酸（GLA）的转化减少。在大多数但不是所有的研究中，已经发现GLA的施用改善患有特应性湿疹的患者的临床评估的皮肤状况、客观评估的皮肤粗糙度和升高的血液儿茶酚胺浓度。特应性湿疹可能是一种轻微的遗传性EFA代谢异常。
Research from the 1930s to the 1950s established that a deficit of n-6 essential fatty acids (EFAs) leads to an inflammatory skin condition in both animals and humans. In a common inherited skin condition, atopic dermatitis (eczema), there was evidence of low blood EFA concentrations and of a therapeutic response to exceptionally high doses of linoleic acid. More recently, it has been established that there is no deficit of linoleic acid in atopic eczema. Concentrations of linoleic acid instead tend to be elevated in blood, milk, and adipose tissue of patients with atopic eczema, whereas concentrations of linoleic acid metabolites are substantially reduced. This suggests reduced conversion of linoleic acid to gamma-linolenic acid (GLA). In most but not all studies, administration of GLA has been found to improve the clinically assessed skin condition, the objectively assessed skin roughness, and the elevated blood catecholamine concentrations of patients with atopic eczema. Atopic eczema may be a minor inherited abnormality of EFA metabolism.