Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements
Repetitive TMS of the motor cortex improves ipsilateral sequential simple finger movements
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DOI：
10.1212/wnl.62.1.91
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发表时间：
2004-01-13
期刊：
影响因子：
9.9
通讯作者：
Pascual-Leone, A
中科院分区：
文献类型：
--
作者：
Kobayashi, M;Hutchinson, S;Pascual-Leone, A
背景：皮质功能的破坏可以改善行为。运动皮层（M1）的跨胼胝体相互作用主要是抑制性的;单侧损伤M1后，未受影响的M1的兴奋性增加。M1的重复经颅磁刺激（rTMS）在相同的M1中产生皮质兴奋性的暂时降低，其持续时间超过rTMS序列的持续时间。作者假设，通过rTMS降低M1的皮质兴奋性，可能通过释放对侧M1的经胼胝体抑制来改善同侧手的运动表现。方法：16名健康志愿者参加。使用食指连续按键任务，运动性能进行监测之前和之后的rTMS（1 Hz，10分钟，强度低于运动阈值）应用于同侧M1，对侧M1，同侧运动前区，或顶点（Cz）。结果：M1的rTMS缩短了同侧手的运动任务的执行时间，而不影响对侧手的表现。这种效应比rTMS持续至少10分钟，对M1刺激具有特异性，并且与未刺激的M1中皮质内兴奋性增加相关。结论：作者的结果支持半球间竞争的概念。“他们证明了重复经颅磁刺激的实用性，以探索未受刺激的对应运动皮层的功能促进，可能是通过抑制受刺激的运动皮层和经胼胝体抑制的活动。
Background: Disruption of cortical function can improve behavior. Motor cortex (M1) transcallosal interactions are mainly inhibitory; after unilateral damage to M1, there is increased excitability of the unaffected M1. Repetitive transcranial magnetic stimulation (rTMS) of M1 produces a temporary reduction in cortical excitability in the same M1 that outlasts the duration of the rTMS train. The authors hypothesize that reducing cortical excitability of M1 by rTMS may improve motor performance in the ipsilateral hand by releasing the contralateral M1 from transcallosal inhibition. Methods: Sixteen healthy volunteers participated. Using a sequential key-pressing task with the index finger, motor performance was monitored before and after rTMS (1 Hz for 10 minutes with the intensity below motor threshold) applied to the ipsilateral M1, contralateral M1, ipsilateral premotor area, or vertex (Cz). Results: rTMS of M1 shortened execution time of the motor task with the ipsilateral hand without affecting performance with the contralateral hand. This effect outlasted rTMS by at least 10 minutes, was specific for M1 stimulation, and was associated with increased intracortical excitability in the unstimulated M1. Conclusions: The authors' results support the concept of an interhemispheric "rivalry." They demonstrate the utility of repetitive transcranial magnetic stimulation to explore the functional facilitation of the unstimulated counterpart motor cortex, presumably via suppression of activity in the stimulated motor cortex and transcallosal inhibition.