Interleukin-6 versus Common Inflammatory Biomarkers for Diagnosing Fracture-Related Infection: Utility and Potential Influencing Factors.
Interleukin-6 versus Common Inflammatory Biomarkers for Diagnosing Fracture-Related Infection: Utility and Potential Influencing Factors.
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Interleukin-6 与常见炎症生物标志物用于诊断骨折相关感染：实用性和潜在影响因素。
DOI：
10.1155/2021/1461638
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发表时间：
2021
影响因子：
4.1
通讯作者：
Yu B
中科院分区：
文献类型：
--
作者：
Zhao XQ;Wan HY;Qin HJ;Jiang N;Yu B
目前，白色血细胞计数（WBC）、红细胞沉降率（ESR）和C-反应蛋白（CRP）用于诊断呼吸道相关感染（FRI）的实用性仍存在争议，而白细胞介素-6（IL-6）作为一种新型细胞因子在辅助诊断FRI中的潜在效率仍不清楚。本研究旨在探讨IL-6及常用生物标志物在FRI诊断中的应用价值及潜在影响因素。比较407例FRI患者和195例复发愈合（FH）患者术前血清IL-6和三种生物标志物水平。采用受试者工作特征（ROC）曲线下面积评价指标的诊断效能，并分析其潜在影响因素。结果显示，FRI患者4种生物标志物的中位数均显著高于FH患者（P < 0.01）。ESR、CRP和IL-6的ROC曲线下面积分别为76.5%、76.4%和71.8%，WBC仅为56.9%。与ESR和CRP相比，IL-6的敏感性较低（ESR vs. CRP vs. IL − 6 = 72.7% vs. 65.6% vs. 57.5%），但特异性较高（ESR vs. CRP vs. IL − 6 = 70.3% vs. 75.4% vs. 83.6%）。血清学IL-6水平受病原体培养结果和病原体数量的影响;然而，细菌类型似乎对四种生物标志物的水平没有影响。提示IL-6与ESR、CRP在FRI的辅助诊断中具有相似的价值。IL-6是否能作为一个有前途的诊断指标还有待进一步研究。
Currently, the utility of white blood cell count (WBC), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP), for diagnosis of fracture-related infection (FRI), is still controversial, and potential efficiency of interleukin-6 (IL-6) as a novel cytokine in assisted diagnosis of FRI remains unclear. This study is aimed at investigating the utility and potential influencing factors of IL-6 and the common biomarkers for diagnosing FRI. Preoperative serological levels of IL-6 and the three biomarkers were compared between 407 FRI patients and 195 fracture-healed (FH) patients. Diagnostic efficiency of the indicators was evaluated using the areas under the receiver operating characteristic (ROC) curves, and their potential influencing factors were also analyzed. Outcomes showed that the median levels of all of the four biomarkers were significantly higher among the FRI patients than those among the FH patients (P < 0.01). The areas below the ROC curves of ESR, CRP, and IL-6 were 76.5%, 76.4%, and 71.8%, respectively, with WBC of only 56.9%. Compared with ESR and CRP, IL-6 displayed a lower sensitivity (ESR vs. CRP vs. IL − 6 = 72.7% vs. 65.6% vs. 57.5%) but a higher specificity (ESR vs. CRP vs. IL − 6 = 70.3% vs. 75.4% vs. 83.6%). Serological IL-6 level was influenced by pathogen culture result and pathogen number; nonetheless, bacteria type appeared to have no influence on the levels of the four biomarkers. In short, this study displayed similar value of IL-6 with that of ESR and CRP in assisted diagnosis of FRI. Whether IL-6 can be regarded as a promising diagnostic indicator requires more studies.
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影响因子：
4.6
作者：
Qin L;Li X;Wang J;Gong X;Hu N;Huang W
通讯作者：
Huang W
影响因子：
5.3
作者：
Kremers, Hilal Maradit;Nwojo, Macaulay E.;Huddleston, Paul M., III
通讯作者：
Huddleston, Paul M., III
DOI：
10.1016/j.injury.2017.08.040
发表时间：
2018-03-01
影响因子：
2.5
作者：
Metsemakers, W. J.;Morgenstern, M.;Verhofstad, M. H. J.
通讯作者：
Verhofstad, M. H. J.
DOI：
10.1038/s41577-021-00553-8
发表时间：
2021-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
Jones SA;Hunter CA
通讯作者：
Hunter CA
影响因子：
3.4
作者：
Panteli M;Giannoudis PV
通讯作者：
Giannoudis PV