Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat
Assessment of cardiac sympathetic regulation by respiratory-related arterial pressure variability in the rat
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DOI：
10.1111/j.1469-7793.1999.887ab.x
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发表时间：
1999-03-15
影响因子：
5.5
通讯作者：
Kuo, TBJ
中科院分区：
文献类型：
--
作者：
Yang, CCH;Kuo, TBJ
1.机械通气引起相应的动脉压变异性(APV)，而APV可被β-肾上腺素能受体拮抗而降低。因此，本研究旨在探讨呼吸相关APV是否可用于评价心脏交感神经张力。将计算机生成的宽带机械通气(0~3 Hz)应用于氯胺酮麻醉和潘库溴铵麻痹的SpragueDawley大鼠。APV及其与肺容量变异性(LVV-APV)的关系采用自频域分析或交叉频谱分析进行系统量化。心得安在0.01~1 mg kg(-1)范围内对0.5~1.5赫兹的APV和LVV-APV传递幅度呈剂量依赖性抑制，而动脉压无明显变化。通过使用脉搏轮廓法评估的每搏量变异性，显示出心得安抑制的相似模式。相反，心得安并没有降低心率变异性。心得安对呼吸相关APV的影响在酚妥拉明和阿托品联合阻断α-肾上腺素受体和M受体的情况下持续存在。LVV-APV传递幅度与心脏交感神经张力相关的频率范围为0.5-1.0 Hz。在氯胺酮麻醉和正压通气的大鼠中，呼吸相关APV可提供独立于副交感和血管交感神经影响的心脏交感神经调节的有效评估。
1. Mechanical ventilation evokes a corresponding arterial pressure variability (APV) which is decreased by beta-adrenoceptor antagonism Therefore, in this study we set out to determine whether the respiratory-related APV can be used to assess cardiac sympathetic tone.2. Computer-generated broad-band mechanical ventilation (0-3 Hz) was applied to Sprague-Dawley rats that had been anaesthetized with ketamine and paralysed with pancuronium. APV and its relationship to lung volume variability (LVV-APV) was systematically quantified with auto- or cross-spectral frequency domain analysis.3. APV and LVV-APV transfer magnitudes between 0.5 and 1.5 Hz show ed dose-dependent suppression by propranolol from 0.01 to 1 mg kg(-1) while the static value of arterial pressure remained unchanged. Stroke volume variability, assessed by the use of a pulse contour method, exhibited a similar pattern of suppression by propranolol. In contrast, heart rate variability was not lowered with propranolol.4. The effect of propranolol on respiratory-related APV persisted wen in the presence of combined alpha-adrenoceptor and muscarinic receptor blockade by phentolamine and atropine.5. The frequency range of 0.5-1.0 Hz was optimal for LVV-APV transfer magnitude to correlate with cardiac sympathetic tone.6. We conclude that respiratory-related APV may provide a valid assessment of cardiac sympathetic regulation which is independent of parasympathetic and vascular sympathetic influences in ketamine-anaesthetized and positive pressure-ventilated rats.