Stimulatory or inhibitory effects of angiotensin II upon LH secretion in ovariectomized rats: a function of gonadal steroids.
Stimulatory or inhibitory effects of angiotensin II upon LH secretion in ovariectomized rats: a function of gonadal steroids.
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血管紧张素 II 对卵巢切除大鼠 LH 分泌的刺激或抑制作用：性腺类固醇的功能。
DOI：
10.1159/000124077
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发表时间：
1985
影响因子：
4.1
通讯作者：
Ganong,WF
中科院分区：
文献类型：
--
作者：
Steele,MK;Gallo,RV;Ganong,WF
研究了人工脑脊液（aCSF）或血管紧张素II （AII）对去卵巢大鼠LH分泌的影响。在未治疗的去卵巢大鼠中，输注aCSF或15 ng AII/h不影响LH的平均全血浓度以及LH脉冲的振幅、频率和最低点，但在输注150或600 ng/h的AII时呈剂量依赖性抑制。AH受体拮抗剂saralasin阻断了AII的抑制作用，证明了对AII反应的特异性。在经雌二醇预处理的去卵巢大鼠中，输注AII没有改变平均血LH水平。然而，在经雌二醇和黄体酮预处理的去卵巢大鼠中，以150或600 ng/h输注AII会产生平均LH浓度的剂量依赖性增加。结果表明，AII对LH分泌既有抑制作用，也有刺激作用，其作用方向由性腺激素决定。
The effects of intraventricular infusions of artificial cerebrospinal fluid (aCSF) or angiotensin II (AII) on LH secretion were investigated in rats that had been ovariectomized for 8 days. In untreated ovariectomized rats, the mean whole blood concentration of LH as well as the amplitude, frequency, and nadir of the LH pulses were not affected by infusion of aCSF or 15 ng AII/h, but were suppressed in a dose-dependent fashion by infusion of AII at doses of 150 or 600 ng/h. The AH receptor antagonist, saralasin, blocked the inhibitory effect of AII, demonstrating the specificity of the response to AII In ovariectomized rats pretreated with estradiol, infusion of AII did not modify mean blood LH levels. However, in ovariectomized rats pretreated with both estradiol and progesterone, infusions of AII at 150 or 600 ng/h produced dose-dependent increases in mean LH concentrations. The results demonstrate both inhibitory and stimulatory effects of AII upon LH secretion, the direction of the effect being determined by gonadal steroids.