Epithelial-immune cell interaction in dry eye.
Epithelial-immune cell interaction in dry eye.
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DOI：
10.1097/ico.0b013e31817f4075
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发表时间：
2008-09
期刊：
影响因子：
2.8
通讯作者：
Stern ME
中科院分区：
文献类型：
--
作者：
Pflugfelder SC;de Paiva CS;Li DQ;Stern ME
干眼症是先天免疫系统和适应性免疫系统的强烈刺激。在干眼炎症/免疫反应的联系是眼表上皮和骨髓源性免疫细胞之间的动态相互作用。一方面，眼表上皮细胞在这种炎症反应中起着关键的启动作用。另一方面，它们是被激活的T细胞产生的细胞因子的靶标，这些细胞在干眼症时被招募到眼表。本文将对干眼症中上皮细胞与免疫细胞的相互作用进行综述。
Dry eye is a potent stimulus of both innate and adaptive immune systems. At the nexus of the dry eye inflammatory/immune response is the dynamic interplay between the ocular surface epithelia and the bone marrow–derived immune cells. On the one hand, ocular surface epithelial cells play a key initiating role in this inflammatory reaction. On the other hand, they are targets of cytokines produced by activated T cells that are recruited to the ocular surface in response to dry eye. This interaction between epithelial and immune cells in dry eye will be thoroughly reviewed.