Synergistic efficacy of combination of enfuvirtide and sifuvirtide, the first- and next-generation HIV-fusion inhibitors
Synergistic efficacy of combination of enfuvirtide and sifuvirtide, the first- and next-generation HIV-fusion inhibitors
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DOI：
10.1097/qad.0b013e328325a4cd
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发表时间：
2009-03-13
期刊：
影响因子：
3.8
通讯作者：
Jiang, Shibo
中科院分区：
文献类型：
--
作者：
Pan, Chungen;Lu, Hong;Jiang, Shibo
恩夫韦肽和西夫韦肽是第一代和下一代HIV融合抑制剂，含有不同的功能结构域，具有不同的靶位点。在这里，我们发现恩夫韦肽和西夫韦肽的组合在抑制HIV-1介导的细胞-细胞融合和X4和R5以及恩夫韦肽耐药HIV-1菌株的感染方面产生了有效的协同作用。这些发现表明，联合应用恩夫韦肽和西夫韦肽可能会改善其疗效和耐药性，从而减少药物使用的剂量和频率。
Enfuvirtide and sifuvirtide, the first- and next-generation HIV-fusion inhibitors, contain different functional domains and have distinct target sites. Here, we found that a combination of enfuvirtide and sifuvirtide resulted in potent synergism in inhibiting HIV-1-mediated cell-cell fusion and infection by X4 and R5 as well as enfuvirtide resistant HIV-1 strains. These findings suggest that application of enfuvirtide and sifuvirtide in combination may improve their efficacy and resistant profile, leading to a reduction of the dosage and frequency of drug use.