Osteoclast cell fusion: mechanisms and molecules
Osteoclast cell fusion: mechanisms and molecules
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DOI：
10.3109/s10165-008-0051-2
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发表时间：
2008-04
影响因子：
2.2
通讯作者：
M. Ishii;Y. Saeki
中科院分区：
文献类型：
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作者：
M. Ishii;Y. Saeki
破骨细胞是骨吸收的多核多核体，其对于骨重建是必需的，并且通过单核巨噬细胞/单核细胞系造血前体的细胞融合形成。在关节炎关节中，可以检测到大量活化的破骨细胞，这被认为是类风湿性关节炎中骨侵蚀的原因。已经完全确定，破骨细胞生成受几个关键的必需因子如M-CSF和RANKL的关键调节。然而，关于其最具特征的特性，即，尽管有几种分子已被证明与这一过程密切相关，但对于细胞融合形成巨大的多核体，仍有许多问题有待澄清。在这里，我们回顾了最新的知识破骨细胞融合和新的概念的特点现象。由于细胞融合是成熟破骨细胞的一个真正的属性，调节这一过程将成为未来骨吸收障碍的一个有前途的治疗工具。
Osteoclasts are bone-resorbing multinuclear polykaryon that are essential for bone remodeling and are formed through cell fusion of mononuclear macrophage/monocyte-lineage hematopoietic precursors. In arthritic joints, a large number of activated osteoclasts can be detected, which are suggested to be causative of bone erosion in rheumatoid arthritis. It has been fully established that osteoclastogenesis is critically regulated by several key essential factors, such as M-CSF and RANKL. However, regarding their most characteristic property, i.e., cell fusion to form giant polykaryons, there are still miscellaneous questions to be clarified, although several molecules have been shown to be critically involved in this process. Here we review the latest knowledge about osteoclastogenic cell fusion and novel concepts underlying the characteristic phenomenon. Because cell fusion is a genuine property of mature osteoclasts, modulating this process will become a promising therapeutic tool for bone resorptive disorders in the future.