Effect of load on the bone around bone-anchored amputation prostheses
Effect of load on the bone around bone-anchored amputation prostheses
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DOI：
10.1002/jor.23352
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发表时间：
2017-05-01
影响因子：
2.8
通讯作者：
Palmquist, Anders
中科院分区：
文献类型：
--
作者：
Stenlund, Patrik;Trobos, Margarita;Palmquist, Anders
骨整合经股截肢假体作为传统的套孔型假体的替代方法已被证明是成功的。该方法改善了假体的使用，从而增加了对骨植入系统的要求。本研究的假设是，施加在截肢者骨锚定植入系统上的载荷会导致骨组织的高应力和应变转移，从而导致并发症，如不利的骨重塑和/或炎症反应升高和/或组织-基台界面的密封功能受损。在研究中，对截肢者进行了特定地点的加载测量，并将其作为有限元分析的输入数据，以预测骨组织中的应力和应变分布。此外，为了评估基台周围的长期组织反应，从接受种植体翻修的患者身上提取的组织样本进行了表征。在本实验评估的骨性能范围内，可以得出结论，施加在种植体系统上的载荷可能会损害骨与基台之间的密封功能，导致与基台直接接触的骨在最远端被吸收。在临床样本中观察到的骨吸收和沿基台界面形成的软组织衬里支持了这一点。(c) 2016年骨科研究会。Wiley期刊公司出版。[J]中华口腔医学杂志，2017,31(5):513 - 522。
Osseointegrated transfemoral amputation prostheses have proven successful as an alternative method to the conventional socket-type prostheses. The method improves prosthetic use and thus increases the demands imposed on the bone-implant system. The hypothesis of the present study was that the loads applied to the bone-anchored implant system of amputees would result in locations of high stress and strain transfer to the bone tissue and thus contribute to complications such as unfavourable bone remodeling and/or elevated inflammatory response and/or compromised sealing function at the tissue-abutment interface. In the study, site-specific loading measurements were made on amputees and used as input data in finite element analyses to predict the stress and strain distribution in the bone tissue. Furthermore, a tissue sample retrieved from a patient undergoing implant revision was characterized in order to evaluate the long-term tissue response around the abutment. Within the limit of the evaluated bone properties in the present experiments, it is concluded that the loads applied to the implant system may compromise the sealing function between the bone and the abutment, contributing to resorption of the bone in direct contact with the abutment at the most distal end. This was supported by observations in the retrieved clinical sample of bone resorption and the formation of a soft tissue lining along the abutment interface. (c) 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:1113-1122, 2017.