ORIGINAL ANTIGENIC SIN IN DENGUE
ORIGINAL ANTIGENIC SIN IN DENGUE
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DOI：
10.4269/ajtmh.1983.32.154
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发表时间：
1983-01-01
影响因子：
3.3
通讯作者：
SANGKAWIBHA, N
中科院分区：
文献类型：
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作者：
HALSTEAD, SB;ROJANASUPHOT, S;SANGKAWIBHA, N
对8名因登革热休克综合征住院前、住院期间和住院后3-5个月的泰国儿童进行了连续的血液样本采集。急性期和恢复期血清中的血凝抑制抗体反应证明，所有患者都经历了二级抗体反应。从2例患者身上检出登革2型病毒。在他们患病前的血液样本中，所有儿童都有单型中和抗体；5人感染登革热1型，2人感染登革热3型，1人感染登革热4型。急性期和恢复期晚期血清中和抗体效价最高的是初始感染病毒型。原抗原抗体反应的存在被记录为顺序登革热感染。有可能应用这一现象来确定继发性登革热感染个体的初始登革热血清型感染，从而有助于澄清登革热休克综合征的发病原因。
Sequential blood samples were obtained from 8 Thai children before, during and 3-5 mo. after hospitalization for dengue shock syndrome. All patients experienced a secondary-type antibody response as evidenced by hemagglutination-inhibition antibody responses in acute and convalescent sera. Dengue 2 viruses were recovered from 2 patients. In their pre-illness blood sample, all children had monotypic neutralizing antibodies; 5 to dengue 1, 2 to dengue 3, and 1 to dengue 4. The highest neutralizing antibody titers in acute phase and late convalescent sera were to the initial infecting virus type. The existence of an original antigenic sin antibody response is documented for sequential dengue infections. It may be possible to apply this phenomenon to identify initial dengue serotype infection in individuals experiencing secondary dengue infections, thus helping to clarify the antecedents to dengue shock syndrome.