Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease
Gas exchange and exercise capacity affect neurocognitive performance in patients with lung disease
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DOI：
10.1097/01.psy.0000160479.99765.18
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发表时间：
2005-05-01
影响因子：
3.3
通讯作者：
Palmer, S
中科院分区：
文献类型：
--
作者：
Parekh, PI;Blumenthal, JA;Palmer, S
目的：本研究探讨等待肺移植患者的认知功能与潜在肺部疾病严重程度之间的关系。方法：94名终末期肺病患者完成了一组测试，以评估两个领域的认知表现：执行功能/注意力（Trails a和B， COWA，动物命名，Stroop颜色-单词测试，数字符号和2 & 7测试）和言语记忆（数字向后和向前跨越，WMS-R逻辑记忆和配对言语联想）。结果：37%的患者在两次或两次以上的测试中表现出中度至重度认知障碍。调整年龄和受教育程度后，执行功能或言语记忆作为特定肺部疾病诊断的功能，在统计学上没有显著差异。较低的二氧化碳分压值与执行功能和注意力的潜在测量的更好的认知表现（p = 0.006）和言语记忆（p = 0.009）相关，而较高的二氧化碳分压值往往与执行功能/注意力测量的更好的表现相关（p = 0.064）。6分钟步行距离与言语记忆呈正相关（p < 0.023）。结论：神经认知功能受损可能在等待肺移植的患者中相对常见，并与肺气体交换无效和运动耐量降低有关。
Objective: This study examined the relationship between cognitive functioning and the severity of underlying lung disease in patients awaiting lung transplantation. Methods: Ninety-four patients with end-stage lung disease completed a test battery to assess cognitive performance in two domains: executive functioning/attention (Trails A and B, COWA, Animal Naming, Stroop Color-Word Test, Digit Symbol, and the 2 & 7 Test) and verbal memory (Digit Span-Backward and Forward, WMS-R Logical Memory and Paired Verbal Associates). Results: Thirty-seven percent of the patients demonstrated moderate to severe cognitive impairment data on two or more tests. Adjusting for age and education, there were no statistically significant differences on executive functioning or verbal memory as a function of specific lung disease diagnosis. Lower PCO2 values were associated with better cognitive performance on latent measures of executive functioning and attention (p = .006) and verbal memory (p = .009), whereas higher PO2 values tended to be associated with better performance on the executive functioning/attention measure (P = .064). Distance walked in 6 minutes was positively related to verbal memory (p < .023). Conclusions: Impaired neurocognitive functioning may be relatively common in patients awaiting lung transplantation and is associated with ineffective pulmonary gas exchange and reduced exercise tolerance.