Making context memories independent of the hippocampus
Making context memories independent of the hippocampus
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DOI：
10.1101/lm.1385409
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发表时间：
2009-07-01
影响因子：
2
通讯作者：
Sutherland, Robert J.
中科院分区：
文献类型：
--
作者：
Lehmann, Hugo;Sparks, Fraser T.;Sutherland, Robert J.
我们提供的证据表明，某些学习参数可以使记忆，甚至是最近的记忆，独立于海马体。我们证实了早期的发现，海马体的损伤会导致情境记忆的严重逆行性失忆，但我们表明，重复的学习过程会创造一种情境记忆，这种记忆不会受到损伤的影响。研究结果表明，通常依赖海马体的记忆在其他记忆网络中随着额外的学习而逐渐加强。后者为海马体逆行性健忘症的模式以及记忆如何独立于海马体提供了新的解释。
We present evidence that certain learning parameters can make a memory, even a very recent one, become independent of the hippocampus. We confirm earlier findings that damage to the hippocampus causes severe retrograde amnesia for context memories, but we show that repeated learning sessions create a context memory that is not vulnerable to the damage. The findings demonstrate that memories normally dependent on the hippocampus are incrementally strengthened in other memory networks with additional learning. The latter provides a new account for patterns of hippocampal retrograde amnesia and how memories may become independent of the hippocampus.