Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation
Direct stenting for stable angina pectoris is associated with reduced periprocedural microcirculatory injury compared with stenting after pre-dilation
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DOI：
10.1016/j.jacc.2007.11.059
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发表时间：
2008-03-18
影响因子：
24
通讯作者：
De Bruyne, Bernard
中科院分区：
文献类型：
--
作者：
Cuisset, Thomas;Hamilos, Michatis;De Bruyne, Bernard
目的我们进行了一项随机研究，比较直接支架植入术（DS）和传统支架植入术（CS）对术后微循环阻力指数（IMR）值的影响。微循环阻力指数是反映冠状动脉微血管阻力的敏感指标。所有患者均患有稳定型心绞痛（加拿大心血管学会分级0.03 ng/ml）。有肌钙蛋白升高的患者PCI后IMR值显著高于无肌钙蛋白升高的患者：24.7 +/- 413.2 vs 16.9 +/- 10.2; p = 0.04。
Objectives We conducted a randomized study to compare the effect of direct stenting (DS) and conventional stenting (CS) on post-procedural index of microcirculatory resistance (IMR) values.Background Direct stenting has been suggested to reduce periprocedural microcirculatory injury compared with stenting that follows pre-dilation (CS). The index of microcirculatory resistance is a sensitive invasive marker of coronary microvascular resistance.Methods Fifty patients admitted for elective percutaneous coronary intervention (PCI) were included. All patients had stable angina (Canadian Cardiovascular Society class 0.03 ng/ml). Patients with troponin elevation had significantly greater post-PCI IMR values than patients without troponin elevation: 24.7 +/- 413.2 versus 16.9 +/- 10.2; p = 0.04.Conclusions In patients undergoing successful coronary stenting for stable angina, DS is associated with reduced microvascular dysfunction induced by PCI as compared with CS.