Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea.
Circulating carbon monoxide level is elevated after sleep in patients with obstructive sleep apnea.
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DOI：
10.1378/chest.07-2904
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发表时间：
2008-11
期刊：
影响因子：
9.6
通讯作者：
Masayoshi Kobayashi;N. Miyazawa;M. Takeno;Shuji Murakami;Y. Kirino;Akiko Okouchi;T. Kaneko;Y. Ishigatsubo
中科院分区：
文献类型：
--
作者：
Masayoshi Kobayashi;N. Miyazawa;M. Takeno;Shuji Murakami;Y. Kirino;Akiko Okouchi;T. Kaneko;Y. Ishigatsubo
阻塞性睡眠呼吸暂停（OSA）患者心血管疾病发病风险增加。本研究旨在确定循环一氧化碳（CO）水平，这已被认为是OSA患者心血管风险的标志物。方法35例OSA患者和17例年龄匹配的健康对照者在多导睡眠监测前后采集静脉血。采用气相色谱法和酶联免疫吸附法分别测定静脉血CO和血清血红素氧合酶（HO）-1浓度。结果OSA患者循环CO水平在早晨显著升高，而在晚上不显著。CO水平的变化被定义为睡眠前和睡眠后CO水平之间的差距，与呼吸暂停低通气指数和缺氧持续时间占总睡眠时间的百分比相关。OSA患者血清HO-1水平与对照组无显著性差异。持续气道正压通气（CPAP）治疗导致睡眠后CO水平正常化。结论：睡眠后循环CO水平有助于评估OSA的临床严重程度。此外，用CPAP治疗OSA可以潜在地降低疾病相关的心血管事件的风险。
BACKGROUND Patients with obstructive sleep apnea (OSA) have an increased risk of cardiovascular morbidity. This study aimed to determine circulating carbon monoxide (CO) levels, which have been suggested to be a marker of cardiovascular risk in patients with OSA. METHODS Venous blood samples were obtained from 35 patients with OSA and 17 age-matched, healthy control subjects before and after polysomnography. Concentrations of venous CO and serum heme oxygenase (HO)-1 were determined by gas chromatography and enzyme-linked immunosorbent assay, respectively. RESULTS Circulating CO levels in OSA patients were significantly increased in the morning, but not in the evening. The change in CO level, which was defined as a gap between the presleep and postsleep CO levels, correlated with apnea-hypopnea index and hypoxia duration as a percentage of total sleep time. No difference was found in serum HO-1 levels between OSA patients and control subjects. Treatment with continuous positive airway pressure (CPAP) resulted in normalization of the postsleep CO level. CONCLUSIONS The postsleep circulating CO level is helpful for assessing the clinical severity of OSA. Moreover, treatment of OSA with CPAP can potentially reduce the risk of the disease associated cardiovascular events.