Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure.
Respiratory uptake and elimination of ethylene glycol monoethyl ether after experimental human exposure.
复制标题
人体实验暴露后乙二醇单乙醚的呼吸摄取和消除。
DOI：
10.1136/oem.43.8.544
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
R. Masschelein
中科院分区：
文献类型：
--
作者：
D. Groeseneken;H. Veulemans;R. Masschelein
10名男性志愿者在不同暴露浓度和体力负荷条件下暴露于乙二醇单乙醚(EGEE)。在所有实验条件下，在曝光期开始后立即达到保留量、大气清除量和摄取率的稳定水平。保留率很高(静息状态下为%)，并随着暴露期间进行体育锻炼而增加。大气清晰度随肺通气率的增加而增加。随着暴露浓度和/或肺通气率的增加，摄取率增加。个体摄取似乎主要受运输机制(肺通气或心输出量，或两者兼而有之)的支配，而不受人体测量因素的影响。未改变的EGEE的呼吸排出量占总摄入量的0.4%以下。暴露后呼吸浓度在停止暴露后的第一分钟内迅速下降，之后观察到的下降速度要慢得多。这种缓慢的下降可以用包含两个指数项的回归方程来描述，表明至少涉及两个药理间隔。
Ten male volunteers were exposed to ethylene glycol monoethyl ether (EGEE) under various conditions of exposure concentration and physical workload. Steady state levels of retention, atmospheric clearance, and rate of uptake were reached immediately after the start of the exposure period for all experimental conditions. Retention was high (64% in resting condition) and increased as physical exercise was performed during exposure. Atmospheric clearance increased as the pulmonary ventilation rate increased. The rate of uptake was higher as exposure concentration or pulmonary ventilation rate, or both, increased. Individual uptake appeared to be governed mainly by transport mechanisms (pulmonary ventilation or cardiac output or both) and not by anthropometric factors. Respiratory elimination of unchanged EGEE accounted for less than or equal to 0.4% of the total body uptake. Postexposure breath concentrations declined rapidly during the first minutes after cessation of exposure, after which a much slower decrease was observed. This slow decrease could be described by a regression equation containing two exponential terms indicating that at least two pharmacological compartments are concerned.