Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?
Can voxel based morphometry, manual segmentation and automated segmentation equally detect hippocampal volume differences in acute depression?
复制标题
DOI：
10.1016/j.neuroimage.2008.11.006
复制
发表时间：
2009-03-01
期刊：
影响因子：
5.7
通讯作者：
Fossati, Philippe
中科院分区：
文献类型：
--
作者：
Bergouignan, Loretxu;Chupin, Marie;Fossati, Philippe
背景：根据荟萃分析，抑郁症与海马体较小有关。大多数中年急性抑郁症患者的磁共振成像（MRI）研究都是基于海马体的手动分割。很少有研究使用基于体素的形态测量（VBM）或自动分割等自动化方法来克服手动分割的某些缺点（本质上是评估者内部和评估者之间的变异性和操作时间消耗）。 目的：我们研究的目的是比较手动分割、自动分割和 VBM 检测中年急性抑郁人群海马结构变化的敏感性。方法：使用带有 SPM5 的 VBM、手动分割和自动分割算法。 VBM-ROI 分析使用两种不同的归一化方法进行：SPM5 中实施的标准方法和最新的 DARTEL 算法。结果：使用 VBM-DARTEL，在进行多重比较校正时，通过 ROI 分析，在不同区域的组之间检测到显着的体积差异，更具体地说是在海马体中。而使用标准 VBM（无 DARTEL）时，ROI 分析并未显示组间双侧体积差异。使用手动分割还检测到患者和对照组之间海马体积显着减少（-11.6% 体积减少，p
Context: According to meta-analyses, depression is associated with a smaller hippocampus. Most magnetic resonance imaging (MRI) studies among middle aged acute depressed patients are based on manual segmentation of the hippocampus. Few studies used automated methods such as voxel-based morphometry (VBM) or automated segmentation that can overcome certain drawbacks of manual segmentation (essentially intra-and inter-rater variability and operator time consumption).Objective: The aim of our study was to compare the sensitivity of manual segmentation, automated segmentation and VBM to detect hippocampal structural changes in middle aged acute depressed population.Method: Twenty-one middle aged depressed inpatients and 21 matched controls were compared regarding their hippocampal structure using VBM with SPM5, manual segmentation and an automated segmentation algorithm. The VBM-ROI analysis was performed using two different normalization methods: the standard approach implemented in SPM5 and the most recent DARTEL algorithm.Results: Using VBM-DARTEL, when corrected for multiple comparisons, significant volume differences were detected between groups in different regions and more specifically in hippocampus with ROI analyses. Whereas using standard VBM (without DARTEL), ROI analyses did not show bilateral volume between group differences.Significant hippocampal volume reductions between patients and controls were also detected using manual segmentation (-11.6% volume reduction, p