Building a Science of Individual Differences from fMRI.
Building a Science of Individual Differences from fMRI.
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DOI：
10.1016/j.tics.2016.03.014
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发表时间：
2016-06
影响因子：
19.9
通讯作者：
Adolphs R
中科院分区：
文献类型：
--
作者：
Dubois J;Adolphs R
迄今为止，功能磁共振成像研究主要关注通过对多个受试者的数据进行平均来证明大脑功能的一般原理。鉴于硬件和分析工具的快速发展，该领域现在准备研究个体受试者的功能磁共振成像测量，并将这些测量与心理特征或遗传变异联系起来。我们讨论当焦点转移到个体受试者时出现的有效性和可靠性问题，这些问题广泛适用于各种成像模式。我们还强调，使用功能磁共振成像对神经功能进行个体评估提出了特定的挑战，并且需要仔细考虑受试者之间的解剖和血管变异性、受试者内变异性的来源和统计功效。
To date, fMRI research has been concerned primarily with evincing generic principles of brain function through averaging data from multiple subjects. Given rapid developments in both hardware and analysis tools, the field is now poised to study fMRI-derived measures in individual subjects, and to relate these to psychological traits or genetic variations. We discuss issues of validity and reliability that arise when the focus shifts to individual subjects and that are widely applicable across imaging modalities. We also emphasize that individual assessment of neural function with fMRI presents specific challenges and necessitates careful consideration of anatomical and vascular between-subject variability, sources of within-subject variability, and statistical power.