Clinical assessment of autism in high-risk 18-month-olds
Clinical assessment of autism in high-risk 18-month-olds
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DOI：
10.1177/1362361308094500
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发表时间：
2008-09-01
期刊：
影响因子：
5.2
通讯作者：
Zwaigenbaum, L.
中科院分区：
文献类型：
--
作者：
Brian, J.;Bryson, S. E.;Zwaigenbaum, L.
早期干预可以改善自闭症谱系障碍 (ASD) 儿童的治疗结果，但现有的识别工具对于 18 个月大的儿童的标准化存在局限性。我们在 18 个月时对患有 ASD 儿童的婴儿兄弟姐妹的高风险队列中评估了 ASD 的潜在行为标志物。使用自闭症诊断观察量表 (ADOS) 和婴儿自闭症观察量表 (AOSI) 对 155 名婴儿兄弟姐妹和 73 名低风险对照者在 18 个月时收集前瞻性数据。根据 3 岁时的盲法最佳估计诊断，将婴儿分为三组（ASD 同胞、非 ASD 同胞、对照）。Fisher 的精确测试和判别功能分析表明，大多数信息丰富的 ADOS 项目来自社会和行为领域，而测量行为反应和运动控制的 AOSI 项目提供了额外的信息。研究结果强调，在评估疑似患有自闭症谱系障碍的幼儿时，不仅要考虑社交沟通缺陷，还要考虑气质的基本维度，包括国家监管和运动控制。
Earlier intervention improves outcomes for children with autism spectrum disorders (ASDs), but existing identification tools are at the limits of standardization with 18-month-olds. We assessed potential behavioural markers of ASD at 18 months in a high-risk cohort of infant siblings of children with ASD. Prospective data were collected using the Autism Diagnostic Observation Schedule (ADOS) and Autism Observation Scale for Infants (AOSI) on 155 infant siblings and 73 low-risk controls at 18 months. Infants were classified into three groups (ASD sibs, non-ASD sibs, controls) based on blind best-estimate diagnosis at age 3. Fisher's exact tests, followed by discriminant function analyses, revealed that the majority of informative ADOS items came from the social and behavioural domains, and AOSI items measuring behavioural reactivity and motor control contributed additional information. Findings highlight the importance of considering not only social-communication deficits, but also basic dimensions of temperament including state regulation and motor control when assessing toddlers with suspected ASD.