Association between pentraxin 3 levels and aortic valve calcification
Association between pentraxin 3 levels and aortic valve calcification
复制标题
五聚蛋白 3 水平与主动脉瓣钙化之间的关联
作者：
NORIMATSU;K.;MIURA;S.;SUEMATSU;Y.;SHIGA;Y.;MIYASE;Y.;NAKAMURA;A.;ZHANG;B. & SAKU;K.
主动脉瓣钙化（AVC）反映了主动脉瓣硬化（AVS）的状态，是主动脉瓣狭窄（AS）的前兆。因此，我们调查了存在的AVC患者进行冠状动脉计算机断层扫描血管造影术（CTA），这是一个有效的工具，用于评估早期的AVC，并检查血浆水平的正五聚蛋白3（PTX 3）和AVC.Methods和resultsThe主题包括162个连续的患者进行CTA和在其中，我们可以测量血浆水平的PTX 3之间的关联。根据CT评估，我们将患者分为AVC组（n= 42）和非AVC组（n= 120）。此外，我们将无AS的患者（经超声心动图评估）分为非AS AVC组（n= 23）和非AS非AVC组（n= 60）。我们通过逻辑回归分析分析了所有患者中存在AVC的预测因素。除年龄、慢性肾病和冠状动脉钙化外，AVC与PTX 3独立相关。我们还研究了无AS患者存在AVC的预测因素。除年龄外，PTX 3是无AS患者存在AVC的独立预测因子。最后，我们发现在包含年龄的模型中加入PTX 3可以提高特异性，从而提高AVC的阳性预测值。结论PTX 3除了年龄外，还可以作为非AS患者AVC的独立预测因子。年龄和PTX 3的组合可能是一个更好的方法来评估AVC比这两者单独。
ObjectiveAortic valve calcification (AVC) reflects the state of aortic valve sclerosis (AVS), which is a precursor to aortic valve stenosis (AS). Therefore, we investigated the presence of AVC in patients who underwent coronary computed tomography angiography (CTA), which is an effective tool for evaluating early-stage AVC, and examined the association between plasma levels of pentraxin 3 (PTX3) and AVC.Methods and resultsThe subjects consisted of 162 consecutive patients who underwent CTA and in whom we could measure plasma levels of PTX3. We divided the patients into an AVC group (n= 42) and a non-AVC group (n= 120), as assessed by CT. Furthermore, we divided the patients without AS, assessed by echocardiography, into non-AS AVC (n= 23) and non-AS non-AVC groups (n= 60). We analyzed the predictors of the presence of AVC in all patients by a logistic regression analysis. AVC was independently associated with PTX3, in addition to age, chronic kidney disease, and coronary artery calcification. We also examined the predictors of the presence of AVC in patients without AS. PTX3, in addition to age, was an independent predictor of the presence of AVC in patients without AS. Finally, we found that adding PTX3 to the model containing age improves the specificity and, therefore, positive predictive value for AVC.ConclusionsPTX3, in addition to age, was shown to be an independent predictor of AVC in patients without AS. The combination of age and PTX3 may be a better approach to the evaluation of AVC than either of these alone.