Validation of a one-dimensional model of the systemic arterial tree
Validation of a one-dimensional model of the systemic arterial tree
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DOI：
10.1152/ajpheart.00037.2009
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发表时间：
2009-07-01
影响因子：
4.8
通讯作者：
Stergiopulos, Nikos
中科院分区：
文献类型：
--
作者：
Reymond, Philippe;Merenda, Fabrice;Stergiopulos, Nikos
[10]杨文辉，李文辉，李文辉.系统动脉树的一维模型的验证。美国生理学杂志心脏循环生理学297：H208-H222，2009年。首次发表于2009年5月8日; doi：10.1152/ajpheart.00037.2009。一个分布式模型的人体动脉树，包括所有主要的全身动脉耦合到心脏模型的开发。数值求解一维（1-D）形式的动量和连续性方程，以获得整个系统动脉树的压力和流量。内膜剪切使用Witzig-Womersley理论建模。动脉壁的非线性粘弹性本构关系被认为是。采用变弹性模型对左心室进行建模。远端血管终止于三元件windkende。冠状动脉的建模假设收缩期流动障碍成比例的心室变化的弹性。动脉尺寸取自以前的1-D模型，并扩展到包括脑血管系统的详细描述。弹性性能取自文献。为了验证模型预测，在年轻志愿者中进行了压力和流量的无创测量。用MRI测量大动脉的血流，用超声多普勒测量脑血流，用眼压计测量血压。得到的1-D模型是最完整的，因为它包括动脉树的所有主要部分，占心室-血管相互作用，并包括剪切应力和壁粘弹性的改进的描述。在不同的动脉位置的模型预测比较以及在相同的解剖点测得的流量和压力波，反映了协议的一般特征的“通用1-D模型”和“平均受试者”的志愿者群体。这项研究构成了第一次验证的完整的1-D模型，使用人体压力和流量数据，并支持1-D模型在人体循环中的适用性。
Reymond P, Merenda F, Perren F, Rufenacht D, Stergiopulos N. Validation of a one-dimensional model of the systemic arterial tree. Am J Physiol Heart Circ Physiol 297: H208-H222, 2009. First published May 8, 2009; doi: 10.1152/ajpheart.00037.2009.-A distributed model of the human arterial tree including all main systemic arteries coupled to a heart model is developed. The one-dimensional (1-D) form of the momentum and continuity equations is solved numerically to obtain pressures and flows throughout the systemic arterial tree. Intimal shear is modeled using the Witzig-Womersley theory. A nonlinear viscoelastic constitutive law for the arterial wall is considered. The left ventricle is modeled using the varying elastance model. Distal vessels are terminated with three-element windkessels. Coronaries are modeled assuming a systolic flow impediment proportional to ventricular varying elastance. Arterial dimensions were taken from previous 1-D models and were extended to include a detailed description of cerebral vasculature. Elastic properties were taken from the literature. To validate model predictions, noninvasive measurements of pressure and flow were performed in young volunteers. Flow in large arteries was measured with MRI, cerebral flow with ultrasound Doppler, and pressure with tonometry. The resulting 1-D model is the most complete, because it encompasses all major segments of the arterial tree, accounts for ventricular-vascular interaction, and includes an improved description of shear stress and wall viscoelasticity. Model predictions at different arterial locations compared well with measured flow and pressure waves at the same anatomical points, reflecting the agreement in the general characteristics of the "generic 1-D model" and the "average subject" of our volunteer population. The study constitutes a first validation of the complete 1-D model using human pressure and flow data and supports the applicability of the 1-D model in the human circulation.