Rate-dependent activation of a prefrontal-insular-cerebellar network during passive listening to trains of click stimuli: an fMRI study
Rate-dependent activation of a prefrontal-insular-cerebellar network during passive listening to trains of click stimuli: an fMRI study
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DOI：
10.1097/00001756-200112210-00045
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发表时间：
2001-12-21
期刊：
影响因子：
1.7
通讯作者：
Wildgruber, D
中科院分区：
文献类型：
--
作者：
Ackermann, H;Riecker, A;Wildgruber, D
八名志愿者在被动聆听咔哒声时接受了功能磁共振成像检查。使用参数方法，确定了所考虑的频段（2-6 Hz）的速率响应曲线。中枢听觉通路和目标区域之外的几个大脑结构各自显示出不同的激活模式：在前岛叶水平出现类似于高通（左侧）或低通滤波（右侧）信号系列的速率反应曲线，在左侧额下回内观察到带通样特征（中心频率：3-4 Hz），点击序列速率> 4 Hz会增强右侧额叶回的激活 小脑半球。各种临床和实验数据表明，左脑半球和右脑半球分别充当听觉输入的高通滤波器和低通滤波器（根据频率理论进行双重滤波）。根据目前的功能磁共振成像数据，前岛叶有助于频率函数的双重过滤。此外，这些侧裂内区域似乎与右侧小脑和左侧额下回连接成一个网络，维护听觉-语言域内的解析/计时功能。 NeuroReport 12:4087-4092 (C) 2001 Lippincott Williams & Wilkins。
Eight volunteers underwent fMRI during passive listening to click trains. Using a parametric approach, rate-response profiles across the frequency band considered (2-6 Hz) were determined. Several cerebral structures outside the central-auditory pathways and target areas displayed distinct activation patterns each: rate-response profiles resembling high-pass (left side) or low-pass filtered (right side) signal series emerged at the level of the anterior insula, band-pass like characteristics (center frequency: 3-4 Hz) were observed within the left inferior frontal gyrus, and click train rates >4 Hz yielded enhanced activation of the right cerebellar hemisphere. A variety of clinical and experimental data indicate that the left and right cerebral hemispheres act as high- and low-pass filters, respectively, on auditory input (double filtering by frequency theory). In light of the present fMRI data, the anterior insula contributes to the assumed double filtering by frequency functions. Furthermore, these intrasylvian areas seem to join up with the right cerebellum and the left inferior frontal gyrus to a network subserving parsing/timing functions within the auditory-verbal domain. NeuroReport 12:4087-4092 (C) 2001 Lippincott Williams & Wilkins.