Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus
Fast-acting bactericidal activity of olanexidine gluconate against qacA/B-positive methicillin-resistant Staphylococcus aureus
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DOI：
10.1099/jmm.0.000979
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发表时间：
2019-06-01
影响因子：
3
通讯作者：
Noguchi, Norihisa
中科院分区：
文献类型：
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作者：
Nakaminami, Hidemasa;Takadama, Shunsuke;Noguchi, Norihisa
qacA/B基因是耐甲氧西林金黄色葡萄球菌（MRSA）对防腐剂耐药性的主要决定因素之一。在此，我们通过测定最低杀菌浓度和时间杀灭试验，比较了皮肤防腐剂（包括葡萄糖酸奥兰西定（OLG），一种在日本引入的新型双胍类防腐剂）对临床qacA/B阳性MRSA菌株的速效杀菌活性。我们的研究结果首次提供了数据，表明OLG对qacA/B阳性MRSA的速效杀菌活性高于葡萄糖酸氯己定，即使两者都是双胍类防腐剂。
The qacA/B gene is one of the major determinants of resistance to antiseptics in methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the fast-acting bactericidal activity of skin antiseptics, including olanexidine gluconate (OLG), a new biguanide antiseptic agent introduced in Japan, against clinical qacA/B-positive MRSA strains by determination of minimum bactericidal concentration and time-kill assay. Our findings provide, for the first time, data indicating that the fast-acting bactericidal activity of OLG against qacA/B-positive MRSA is higher than that of chlorhexidine gluconate, even though both are biguanide antiseptics.