Effects of ghrelin on food intake and neuroendocrine function in sheep
Effects of ghrelin on food intake and neuroendocrine function in sheep
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DOI：
10.1016/j.anireprosci.2004.05.001
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发表时间：
2004-07-01
影响因子：
2.2
通讯作者：
Terashima, Y
中科院分区：
文献类型：
--
作者：
Sugino, T;Hasegawa, Y;Terashima, Y
Ghrelin是一种新型的酰化多肽，是生长激素促分泌素（GHS）受体的内源性配体。Ghrelin主要在胃的泌酸腺中产生，但也在肠、肾、下丘脑和脑垂体中产生。循环中的胃饥饿素水平在饭前上升，饭后下降，这表明对进餐的期待可能会刺激分泌。在某些物种中，生长素释放肽给药已显示刺激生长激素（GH）分泌，并通过增加食物摄入和减少脂肪的代谢利用而引起体重增加。此外，脑室内和血管内施用生长素释放肽以剂量依赖性方式增加胃酸排出。因此，Ghrelin可能在控制反刍动物摄食和能量平衡中发挥重要作用。本研究以绵羊为实验动物，探讨了Ghrelin在反刍动物摄食和神经内分泌功能调控中的作用。本文简要综述了生长激素释放肽在摄食时的调节机制，并重点介绍了生长激素释放肽的神经内分泌功能。(C)2004 Elsevier B.V.保留所有权利。
Ghrelin, a novel acylated peptide, is the endogenous ligand for growth hormone secretagogue (GHS) receptor. Ghrelin is produced mainly in the oxyntic glands of the stomach, but also produced in the intestines, kidneys, hypothalamus and pituitary gland. Circulating ghrelin levels have been shown to rise before a meal and fall afterwards, suggesting that anticipation of a meal may stimulate secretion. In some species, ghrelin administration has been shown to stimulate growth hormone (GH) secretion, and to cause weight gain by increasing food intake and reducing metabolic utilization of fat. Furthermore, intracerebroventricular and intravascular administration of ghrelin increases gastric acid output in a dose-dependent manner. Thus, ghrelin may play an important role in controlling feeding behavor and energy homeostasis.We have investigated the role of ghrelin in the control of feeding and neuroendocrine function in ruminants using sheep as an experimental model. This mini review describes mechanisms regulating ghrelin secretion at feeding time, and also focuses on the neuroendocrine functions of ghrelin. (C) 2004 Elsevier B.V. All rights reserved.