A simple method for daily inspections of gas chromatography-mass spectrometry systems with an instrumental detection limit as an indicator
A simple method for daily inspections of gas chromatography-mass spectrometry systems with an instrumental detection limit as an indicator
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以仪器检出限为指标的气相色谱-质谱联用系统日常检查的简便方法
DOI：
10.1016/j.chroma.2021.462570
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发表时间：
2021
期刊：
影响因子：
4.1
通讯作者：
Yozuru Hayashi
中科院分区：
文献类型：
--
作者：
Hiroshi Hasegawa;Akira Kotani;Hideki Hakamata;Kimiyoshi Ichida;Yozuru Hayashi
提出了一种以仪器检测限（IDL）为指标的气相色谱-质谱（GC-MS）系统日常检测的简便方法。ISO对DL的定义为3.3σ，其中σ表示空白测量的标准差（SD）。根据互信息函数（FUMI）理论，利用TOCO 19软件进行了σ的估计。一个IDL是一个信号区，宽度和噪声水平的组合的结论是一个很好的指标，每天检查相比，其每个组成部分。硬脂酸甲酯用作程序升温GC-MS系统日常检查的标准物质。包含目标信号和背景噪声的1800个数据点（1.5 min）的短色谱图适用于TOCO 19的IDL预测。在95%置信区间内，基于理论估计的σ的相对SD（RSD）与重复测量的统计结果一致。观察到柱温通过背景波动影响IDL，然后在170 - 270 °C范围内检查温度-IDL关系。一个多月的实际日常检查证明。
The purpose of this paper is to propose a simple method for daily inspections of a gas chromatography-mass spectrometry (GC–MS) system with an instrumental detection limit (IDL) as an indicator. A definition of DLs by ISO is 3.3σwhereσdenotes the standard deviation (SD) of blank measurements. Estimation ofσis carried out according to the function of mutual information (FUMI) theory and actually with commercial software (TOCO19). An IDL which is a combination of a signal area, width and noise level is concluded to be a good indicator for daily inspections compared with each of its constituents. Methyl stearate is used as a standard material for the daily inspection of a programmed-temperature GC–MS system. A short chromatogram of 1800 data points (1.5 min) containing a target signal and background noise is fit for the IDL prediction by TOCO19. The relative SDs (RSDs) based on the theoretically estimatedσare shown to coincide with statistical results from repeated measurements within 95% confidence intervals. Column temperature is observed to affect IDLs through background fluctuation and then temperature-IDL relationship is examined in a range from 170 to 270 °C. Actual daily inspections over a month are demonstrated.