Vascular smooth muscle actin is reduced in Alzheimer disease brain: A quantitative analysis
Vascular smooth muscle actin is reduced in Alzheimer disease brain: A quantitative analysis
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DOI：
10.1093/jnen/63.7.735
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发表时间：
2004-07-01
影响因子：
3.2
通讯作者：
Hulette, CM
中科院分区：
文献类型：
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作者：
Ervin, JF;Pannell, C;Hulette, CM
我们分析了10例ApoE 4，4例阿尔茨海默病(AD)患者和10例ApoE 3，3 AD患者在年龄、性别和痴呆病程相匹配的脑血管中的SMA免疫反应。我们还检查了10名年龄和性别匹配的认知和神经病理正常对照。蛛网膜下腔血管SMA免疫反应。图像分析对灰质、白质进行定量。与认知和神经病理正常对照组相比，所有AD患者血管中的SMA免疫反应较少(p<；0.001)。此外，ApoE 4.4 AD患者蛛网膜下腔血管的SMA免疫反应性低于ApoE 3，3 AD患者(p<；0.05)。与年龄匹配的认知和神经病理正常对照组相比，AD患者蛛网膜、灰质和白质血管中的血管SMA密度降低。AD组内SMA丢失的严重程度可能取决于ApoE类型。
We analyzed smooth muscle actin (SMA) immunoreactivity in brain blood vessels of 10 ApoE 4,4 Alzheimer disease (AD) patients and 10 ApoE 3,3 AD patients matched for age, sex, and duration of dementia. We also examined 10 cognitively and neuropathologically normal controls matched for age and sex. Vascular SMA immunoreactivity in the arachnoid. grey matter, and white matter was quantified by image analysis. There was less SMA immunoreactivity in blood vessels of all AD patients when compared to cognitively and neuropathologically normal controls (p < 0.001). In addition, arachnoidal vessels of ApoE 4.4 AD patients had less SMA immunoreactivity than ApoE 3,3 AD patients (p < 0.05). There is decreased vascular SMA density in arachnoid, grey matter, and white matter blood vessels in patients with AD when compared to age matched, cognitively and neuropathologically normal controls. The severity of the loss of SMA within the AD group may depend on ApoE type.