An Analysis of Myocardial Infarction: The Effect of Regional Changes in Contractility
An Analysis of Myocardial Infarction: The Effect of Regional Changes in Contractility
复制标题
心肌梗塞分析：收缩力区域变化的影响
DOI：
10.1161/01.res.55.6.805
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发表时间：
1984
影响因子：
20.1
通讯作者：
T. McMahon
中科院分区：
文献类型：
--
作者：
D. Bogen;A. Needleman;T. McMahon
在前面的论文中，我们采用了一个最初的球形，修改后的膜模型的梗死心室，以研究心室功能之间的关系，梗死面积和梗死刚度。在本文中，我们已经应用了相同的模型，一组不同的问题，即，在非梗死心肌的增强或抑制变力状态的后果。当检查包含高达41%梗死的梗死心室时，每搏输出量似乎对变力性状态的增加相对不敏感。然而，当正性肌力状态降低到正常值的80%以下时，每搏输出量福尔斯迅速下降。如果心室有一个大的、弱收缩的节段，并且没有完全梗死，只有当弱区域的收缩力降低到正常的50%以下时，每搏输出量才会受损。最后，梗塞区周围的应力集中似乎更强烈地依赖于非梗塞组织的变力状态，而不是梗塞面积
In a preceding paper, we employed an initially spherical, modified membrane model of the infarcted ventricle to investigate the relation between ventricular function and both infarct size and infarct stiffness. In the present paper, we have applied the same model to a set of different questions, namely, the consequences of enhanced or depressed inotropic state within the noninfarcted myocardium. When infarcted ventricles containing up to 41percent; infarction are examined, stroke volume appears to be relatively insensitive to increases in inotropic state. However, stroke volume falls rapidly when inotropic state is depressed below 80percent; of normal. For the case of a ventricle with a large, weakly contracting segment which is not totally infarcted, stroke volume is impaired only when the contractility of the weak region is diminished below 50percent; of normal. Finally, the stress concentration around a region of infarction appears to be dependent more strongly on the inotropic state of the noninfarcted tissue than on the infarct size