DISPROPORTIONATE LOSS OF NORADRENERGIC AND CHOLINERGIC NEURONS AS CAUSE OF DEPRESSION IN ALZHEIMERS-DISEASE - A HYPOTHESIS
DISPROPORTIONATE LOSS OF NORADRENERGIC AND CHOLINERGIC NEURONS AS CAUSE OF DEPRESSION IN ALZHEIMERS-DISEASE - A HYPOTHESIS
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DOI：
10.1055/s-2007-1014267
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发表时间：
1994-01-01
影响因子：
4.3
通讯作者：
CAIRNS, N
中科院分区：
文献类型：
--
作者：
FORSTL, H;LEVY, R;CAIRNS, N
42名经神经病理学证实患有阿尔茨海默病的患者进行了前瞻性检查，与10名年龄匹配的非痴呆对照组相比，他们的蓝斑、黑质和Meynert基底核的神经元数量显著减少。12例有抑郁史的痴呆患者亚组蓝斑区神经元数量明显减少，基底核Meynert神经元密度略高。我们假设去甲肾上腺素能/胆碱能失衡可能促进阿尔茨海默病患者抑郁特征的发展。
Forty-two patients with neuropathologically confirmed Alzheimer's disease, who had been examined prospectively, had a significant decrease of neuron numbers in the locus coeruleus, substantia nigra, and basal nucleus of Meynert compared to 10 age-matched, non-demented controls. A subgroup of 12 demented patients with a history of depression had significantly lower neuron numbers in the locus coeruleus and slightly higher neuronal density in the basal nucleus of Meynert. We hypothesize that a noradrenergic/cholinergic imbalance may promote the development of depressive features in patients with Alzheimer's disease.