Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease.
Protective Effects of Indian Spice Curcumin Against Amyloid-β in Alzheimer's Disease.
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DOI：
10.3233/jad-170512
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Reddy AP
中科院分区：
文献类型：
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作者：
Reddy PH;Manczak M;Yin X;Grady MC;Mitchell A;Tonk S;Kuruva CS;Bhatti JS;Kandimalla R;Vijayan M;Kumar S;Wang R;Pradeepkiran JA;Ogunmokun G;Thamarai K;Quesada K;Boles A;Reddy AP
本文的目的是评估目前对印度香料"姜黄素"对阿尔茨海默病（AD）发病机制中淀粉样蛋白-β（A β）诱导的毒性的理解。天然产品，如生姜，姜黄素和银杏已被用作饮食和膳食补充剂，以治疗人类疾病，包括癌症，心血管疾病，呼吸系统疾病，传染病，糖尿病，肥胖症，代谢综合征和神经系统疾病。植物提取的产品具有保护作用，包括抗炎、抗氧化、抗关节炎、促进愈合和增强记忆认知功能。在过去的十年中，几个小组已经设计和合成了姜黄素及其衍生物，并使用AD的细胞和小鼠模型进行了广泛的测试。最近对淀粉样蛋白-β和姜黄素的研究表明，姜黄素可防止淀粉样蛋白-β聚集并穿过血脑屏障（BBB），到达脑细胞并保护神经元免受人类衰老和淀粉样蛋白-β的各种毒性损伤。最近的研究还报告说，姜黄素改善认知能力下降，改善AD小鼠模型的突触功能。此外，最近的研究小组已经开始对老年人和AD患者进行研究，目前正在评估这些研究的结果。这篇文章强调了姜黄素对AD的有益作用。本文还批判性地评估了姜黄素生物利用度的当前局限性，以及对新制剂的迫切需求，以增加其脑水平来治疗AD患者。
The purpose of our article is to assess the current understanding of Indian spice ‘Curcumin’ against amyloid-β (Aβ)-induced toxicity in Alzheimer’s disease (AD) pathogenesis. Natural products, such as ginger, curcumin and gingko biloba have been used as diets and dietary supplements to treat human diseases, including cancer, cardiovascular, respiratory, infectious, diabetes, obesity, metabolic syndromes and neurological disorders. Products derived from plants are known to have protective effects, including anti-inflammatory, anti-oxidant, anti-arthritis, pro-healing and boosting memory cognitive functions. In the last decade, several groups have designed and synthesized curcumin and its derivatives and extensively tested using cell and mouse models of AD. Recent research on amyloid-β and curcumin has revealed that curcumin prevents amyloid-β aggregation and crosses the blood brain barrier (BBB), reach brain cells and protect neurons from various toxic insults of aging and amyloid-β in humans. Recent research has also reported that curcumin ameliorates cognitive decline and improves synaptic functions in mouse models of AD. Further, recent groups have initiated studies on elderly individuals and patients with AD and the outcome of these studies is currently being assessed. This article highlights the beneficial effects of curcumin on AD. This article also critically assesses the current limitations of curcumin’s bioavailability and urgent need for new formulation to increase its brain levels to treat patients with AD.