Delayed Echo Enhancement Imaging to Quantify Myocardial Infarct Size.
Delayed Echo Enhancement Imaging to Quantify Myocardial Infarct Size.
复制标题
DOI：
10.1016/j.echo.2021.02.019
复制
发表时间：
2021-08
期刊：
影响因子：
--
通讯作者：
Porter TR
中科院分区：
文献类型：
--
作者：
Zeng P;Qian L;Lof J;Stolze E;El Kadi S;Bargar T;Sklenar J;Matsunaga T;Xie F;Porter TR
由商业微泡配制的全氟丙烷液滴表现出与其母体微泡不同的声学特性，最有可能来自增强的内皮渗透性。这种增强的渗透性可以允许类似于延迟增强磁共振成像（DE-MRI）的延迟回波增强成像（DEEI）。我们假设这将允许检测和量化心肌瘢痕。在15只接受90分钟左前降支（LAD）缺血的猪中，通过球囊（n=13）或血栓闭塞（n=2），在闭塞后2-24天进行DE-MRI。DEEI在静脉内注射1 ml压缩成180 nm液滴的50%Deeprim ®（Lantheus Medical）后2-4分钟进行。在1.7发射/3.4 MHz接收下，使用单脉冲谐波成像（SPHI）对所有猪进行DEEI。对用DEEI观察到的心肌缺损进行定量（%梗死面积），并与DE-MRI以及死后染色进行比较。在6头猪中，进行了间歇性高机械指数（MI）脉冲的多脉冲低机械指数基本非线性成像（FNLI），以确定是否可以用较长的脉冲持续时间实现梗死区内的液滴激活。DE-MRI显示的梗死面积范围为0 ~ 46%。SPHI检测到对比度缺损，其与DE-MRI的梗死面积密切相关（r=0.81，p=0.0001）。FNLI高MI冲动导致梗死区和正常区的液滴激活。FNLI图像的谐波减影导致梗死区增强，这也与梗死面积密切相关（r=0.83; p=0.04）。在死后透射电子显微镜下观察到梗死区和远端正常区的肌细胞内有液滴。使用DEEI技术，可以利用IntraperitoneDehydrogennanodrops在床边检测和量化梗死区。
Perfluoropropane droplets formulated from commercial microbubbles exhibit different acoustic characteristics than their parent microbubbles, most likely from enhanced endothelial permeability. This enhanced permeability may permit delayed echo-enhancement imaging (DEEI) similar to delayed enhancement magnetic resonance imaging (DE-MRI). We hypothesized this would allow detection and quantification of myocardial scar. In 15 pigs undergoing 90 minutes of left anterior descending (LAD) ischemia by either balloon (n=13) or thrombotic occlusion (n=2), DE-MRI was performed at 2-24 days post occlusion. DEEI was performed at 2-4 minutes following an intravenous injection of one ml of 50% Definity® (Lantheus Medical) compressed into 180 nm droplets. DEEI was attempted in all pigs with single pulse harmonic imaging (SPHI) at 1.7 transmit/3.4 MHz receive. Myocardial defects observed with DEEI were quantified (% infarct area) and compared with DE-MRI as well as post mortem staining. In six pigs, multipulse low mechanical index fundamental non-linear imaging (FNLI) with intermittent high mechanical index (MI) impulses was performed to determine if droplet activation within the infarct zone was achievable with a longer pulse duration. The range of infarct size area by DE-MRI ranged from 0 to 46% of total left ventricular area. SPHI detected a contrast defect which correlated closely with infarct area by DE-MRI (r=0.81, p=0.0001). FNLI high MI impulses resulted in droplet activation in both the infarct and normal zones. Harmonic subtraction of the FNLI images resulted in infarct zone enhancement that also correlated closely with infarct size (r=0.83; p=0.04). Droplets were observed on post mortem transmission electron microscopy within myocytes of the infarct and remote normal zone. Intravenously Definity nanodroplets can be utilized to detect and quantify infarct zone at the bedside using DEEI techniques.
登录
查看更多内容
磁共振成像识别的心肌疤痕可以预测冠状动脉搭桥术后左心室功能的改善
影响因子：
3.7
作者：
Yang T;Lu MJ;Sun HS;Tang Y;Pan SW;Zhao SH
通讯作者：
Zhao SH
影响因子：
37.8
作者：
Bulluck H;Dharmakumar R;Arai AE;Berry C;Hausenloy DJ
通讯作者：
Hausenloy DJ
DOI：
10.1073/pnas.1606915113
发表时间：
2016-09-06
影响因子：
11.1
作者：
Helfield, Brandon;Chen, Xucai;Villanueva, Flordeliza S.
通讯作者：
Villanueva, Flordeliza S.
影响因子：
12.4
作者：
Matsunaga TO;Sheeran PS;Luois S;Streeter JE;Mullin LB;Banerjee B;Dayton PA
通讯作者：
Dayton PA
影响因子：
20.1
作者：
Jones, Steven P.;Tang, Xian-Liang;Bolli, Roberto
通讯作者：
Bolli, Roberto