Comparison of [18F]fluorocholine and [18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer
Comparison of [18F]fluorocholine and [18F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer
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DOI：
10.1016/s0022-5347(05)64906-3
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发表时间：
2002-07-01
影响因子：
6.6
通讯作者：
deGrado, TR
中科院分区：
文献类型：
--
作者：
Price, DT;Coleman, RE;deGrado, TR
目的：正电子发射断层扫描（PET）成像用于癌症的代谢评估。[F-18]氟脱氧葡萄糖（FDG）通常用作放射性示踪剂，但其在前列腺癌中的低细胞摄取率限制了其用途。我们评估了新的胆碱类似物[F-18]氟胆碱（FCH）检测雄激素依赖性和雄激素非依赖性前列腺癌，其metabolis.Materials和方法：FCH和FDG的细胞摄取在培养的前列腺癌细胞（LNCaP和PC-3）进行了比较。将FCH和FDG注射到裸鼠移植瘤（CWR-22和PC-3）中，并评估各器官的放射性示踪剂摄取。结果：雄激素依赖性（LNCaP）和非依赖性（PC-3）前列腺癌细胞的FCH摄取分别比FDG摄取高849%和60%。加入半胆碱-3（5 mM.）在放射性示踪剂给药前30分钟，在LNCaP和PC-3细胞中分别抑制了79%和70%的FCH摄取，而FDG摄取没有受到显著影响。尽管裸鼠异种移植物显示FDG摄取等于或大于FCH摄取，但患者的临床成像显示雄激素和雄激素非依赖性前列腺癌患者的FCH摄取高2至4倍（p < 0.001）。更多的病变检测到FCH比FDG在原发肿瘤，骨转移和软组织transferations.Conclusions：在体外数据显示，雄激素依赖性（LNCaP）和雄激素非依赖性（PC-3）前列腺癌细胞的FCH比FDG的摄取。尽管小鼠异种移植数据显示，PC-3肿瘤中FDG的蓄积大于FCH，但人体PET显示，FCH在检测原发性和转移性前列腺癌方面优于FDG。总的来说，本研究的数据表明，FCH比FDG更适合用于前列腺癌的PET，并支持未来在更多受试者中进行验证研究的必要性。
Purpose: Positron emission tomography (PET) imaging is used for the metabolic evaluation of cancer. [F-18]fluorodeoxyglucose (FDG) is commonly used as a radiotracer but its low cellular uptake rate in prostate cancer limits its usefulness. We evaluated the novel choline analog [F-18]fluorocholine (FCH) for detecting androgen dependent and androgen independent prostate cancer, and its metastases.Materials and Methods: The cellular uptake of FCH and FDG was compared in cultured prostate cancer cells (LNCaP and PC-3). FCH and FDG were injected into nude mice xenografts (CWR-22 and PC-3) and radiotracer uptake in various organs were evaluated. Patients with androgen dependent (9) and independent (9) prostate cancer were studied by FCH and FDG PET.Results: FCH uptake was 849% and 60% greater than FDG uptake in androgen dependent (LNCaP) and independent (PC-3) cells, respectively. The addition of hemicholinium-3 (5 mM.) 30 minutes before radiotracer administration inhibited FCH uptake by 79% and 70% in LNCaP and PC-3 cells, respectively, whereas FDG uptake was not significantly affected. Although nude mice xenografts showed that FDG uptake was equal to or greater than FCH uptake, clinical imaging in patients demonstrated 2 to 4-fold higher uptake of FCH in those with androgen and androgen independent prostate carcinoma (p < 0.001). More lesions were detected by FCH than by FDG in primary tumors, osseous metastases and soft tissue metastases.Conclusions: In vitro data demonstrated greater FCH than FDG uptake in androgen dependent (LNCaP) and androgen independent (PC-3) prostate cancer cells. Although the murine xenograft data showed greater accumulation of FDG than FCH in PC-3 tumors, PET in humans showed that FCH was better than FDG for detecting primary and metastatic prostate cancer. Overall the data from this study suggest that FCH is preferable to FDG for PET of prostate carcinoma and support the need for future validation studies in a larger number of subjects.